Modification of anti-hypertensive action of verapamil by inhibition of endogenous prostaglandin synthesis.

Verapamil, a known Ca++ antagonist, has vasodilator properties and is of use in the management of mild to moderate hypertension. It is also known to possess PGE2 antagonistic properties and thus may enhance prostacyclin synthesis of action in the vascular endothelial cells. This may contribute to its antihypertensive action. Blocking of endogenous synthesis of prostaglandins by acetyl salicylic acid reversed the beneficial effect of verapamil in hypertensive patients. This supports the concept that the vasodilator and anti-hypertensive properties of verapamil are mediated in part by the modulation of prostaglandin system.