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Literature DB >> 6955600

Eukaryotic ribosomes can recognize preproinsulin initiation codons irrespective of their position relative to the 5' end of mRNA.

Abstract

The functional assay of a eukaryotic mRNA, into which additional AUG codons have been introduced by in vitro mutagenesis, shows that a translational initiation site need not necessarily be the nearest AUG codon to the 5' end of a mRNA. Hence, the sequence surrounding the AUG, and not simply its position relative to the 5' end of mRNA, appears to be important in determining initiation efficiency.

Entities: Disease Gene

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Year: 1982 PMID： 6955600 DOI： 10.1038/299221a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

27 in total

1. Mechanisms of synthesis of virion proteins from the functionally bigenic late mRNAs of simian virus 40.

Authors: S A Sedman; J E Mertz
Journal: J Virol Date: 1988-03 Impact factor: 5.103

2. Structure and function of the TRP3 gene of Saccharomyces cerevisiae: Analysis of 3'- and 5'-deletions in vivo and in vitro.

Authors: M Aebi; R Furter; F Prantl; P Niederberger; R Hütter
Journal: Curr Genet Date: 1984-04 Impact factor: 3.886

3. Strength of translation initiation signal sequence of mRNA as studied by quantification method: effect of nucleotide substitutions upon translation efficiency in rat preproinsulin mRNA.

Authors: Y Iida; T Masuda
Journal: Nucleic Acids Res Date: 1996-09-01 Impact factor: 16.971

Eukaryotic ribosomes can recognize preproinsulin initiation codons irrespective of their position relative to the 5' end of mRNA.

1. Mechanisms of synthesis of virion proteins from the functionally bigenic late mRNAs of simian virus 40.

2. Structure and function of the TRP3 gene of Saccharomyces cerevisiae: Analysis of 3'- and 5'-deletions in vivo and in vitro.

3. Strength of translation initiation signal sequence of mRNA as studied by quantification method: effect of nucleotide substitutions upon translation efficiency in rat preproinsulin mRNA.

4. In vitro expression of two proteins from overlapping reading frames in a eukaryotic DNA sequence.

Review 5. Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae.

6. Role of the avian retrovirus mRNA leader in expression: evidence for novel translational control.

7. Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes.

8. Leader length and secondary structure modulate mRNA function under conditions of stress.

9. Primary structure of the neutralization antigen of simian rotavirus SA11 as deduced from cDNA sequence.

10. Complete nucleotide sequence of alfalfa mosaic virus RNA 1.