Prevention of experimentally induced cleft palate in mice.

Cleft palate was induced by giving cyclophosphamide (CPA) to pregnant mice on different days of pregnancy. Application of Solcoseryl, an oxygen stimulating, protein-free extract of the blood of calves, modified the teratogenic and embryolethal effect of CPA and significantly decreased the frequency of cleft palate (from over 70% to about 20% in some groups). This study supports the clinical findings of a reduction in the incidence of facial clefting in man following application of Solcoseryl and vitamins (Gabka, 1975).