Literature DB >> 6951094

Prostate adenocarcinoma in rats: induction by 3,2'-dimethyl-4-aminobiphenyl.

S Katayama, E Fiala, B S Reddy, A Rivenson, J Silverman, G M Williams, J H Weisburger.   

Abstract

Five experiments designed for various purposes [mainly for the study of colon carcinogenesis in inbred F344 male rats given sc injections of 3,2'-dimethyl-4-aminobiphenyl (DMAB)] were reviewed as to the production and presence of neoplastic lesions of the prostate gland. The overall incidence of prostate proliferative lesions among 293 animals exposed to DMAB was 32% (95 animals). Early in situ carcinomas were present in 66 animals, larger intra-acinar carcinomas in situ in 28, and invasive carcinoma in 1. None of the control animals in these studies exhibited prostate neoplasms. The conclusion, therefore, is that DMAB can induce adenocarcinomas in the rat prostate gland.

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Year:  1982        PMID： 6951094

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  6 in total

1.  Lack of association of the N-acetyltransferase NAT1*10 allele with prostate cancer incidence, grade, or stage among smokers in Finland.

Authors:  LaCreis R Kidd; David W Hein; Karen Woodson; Philip R Taylor; Demetrius Albanes; Jarmo Virtamo; Joseph A Tangrea
Journal:  Biochem Genet       Date:  2010-10-08       Impact factor: 1.890

2.  Selective induction of prostate carcinomas in F344 rats treated with intraperitoneal injections of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl.

Authors:  T Shirai; A Nakamura; S Fukushima; C Y Wang; H Yamada; N Ito
Journal:  Jpn J Cancer Res       Date:  1990-04

3.  3,2'-Dimethyl-4-aminobiphenyl-induced gallbladder carcinogenesis and effects of ethinyl estradiol in hamsters.

Authors:  R Hasegawa; K Ogawa; K Takaba; T Shirai; N Ito
Journal:  Jpn J Cancer Res       Date:  1992-12

4.  Histopathological analysis of invasive bladder carcinomas induced by 3,2'-dimethyl-4-aminobiphenyl in hamsters.

Authors:  L Cui; R Hasegawa; K Ogawa; Y Yamada; S Takahashi; T Shirai
Journal:  Jpn J Cancer Res       Date:  1996-01

5.  Sequential observation of rat prostate lesion development induced by 3,2'-dimethyl-4-aminobiphenyl and testosterone.

Authors:  T Shirai; K Imaida; S Iwasaki; T Mori; M Tada; N Ito
Journal:  Jpn J Cancer Res       Date:  1993-01

6.  Low tumorigenic response to 3,2'-dimethyl-4-aminobiphenyl administration in the prostate of rats castrated at birth.

Authors:  T Shirai; Y Tagawa; O Taguchi; E Ikawa; M Mutai; S Fukushima; N Ito
Journal:  Jpn J Cancer Res       Date:  1988-12
  6 in total

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