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Literature DB >> 6948770

Biochemical evidence for the non-inactivation of the steroid sulfatase locus in human placenta and fibroblasts.

M Bedin, D Weil, T Fournier, L Cedard, J Frezal.

Abstract

Steroid sulfatase activities are significantly higher in placentas obtained after the birth of girls than after the birth of boys, and also in female fibroblasts compared to male strains. This constitutes biochemical evidence for the non-inactivation of the X-linked sulfatase locus. No hydrolytic activity is found in the fibroblasts of ichthyotic boys. Heterozygosity is demonstrated in the fibroblasts of the four mothers studied, as they have steroid sulfatase activity of less or equivalent to the normal male value.

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Year: 1981 PMID： 6948770 DOI： 10.1007/bf00283675

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

17 in total

6. Biochemical variability of arylsulphatases -A, -B and -C in cultured fibroblasts from patients with multiple sulphatase deficiency.

Authors: P L Chang; N E Rosa; S R Ballantyne; R G Davidson
Journal: J Inherit Metab Dis Date: 1983 Impact factor: 4.982

7. Steroid sulphatase levels are higher in males than in females of the root vole (Microtus oeconomus). Yet another rodent with an active Y-linked allele?

Authors: U H Wiberg; K Fredga
Journal: Hum Genet Date: 1987-09 Impact factor: 4.132

7 in total

Biochemical evidence for the non-inactivation of the steroid sulfatase locus in human placenta and fibroblasts.

1. A study of pregnancy with low estrogen production due to placental sulfatase deficiency.

2. Enzymatic basis of typical X-linked icthyosis.

3. Regulation of steroidogenesis in the human placenta.

4. Placental sulfatase deficiency: clinical and biochemical study of 16 cases.

5. X-linked ichthyosis due to steroid-sulphatase deficiency.

6. Steroid sulphatase deficiency.

7. X-linked icthyosis. A sulphatase deficiency.

8. Regional assignment of the gene locus for steroid sulfatase.

9. Non-inactivation of an x-chromosome locus in man.

10. X-linked steroid sulfatase: evidence for different gene-dosage in males and females.

1. Partial lyonisation of steroid sulphatase gene in single hair roots.

2. Intermediate levels of aryl sulfatase C in human leukocytes of female carriers for X-linked recessive ichthyosis.

3. Recognising placental steroid sulphatase deficiency.

4. Murine arylsulfatase C: evidence for two isozymes.

5. Tissue-specific expression of human arylsulfatase-C isozymes and steroid sulfatase.

6. Biochemical variability of arylsulphatases -A, -B and -C in cultured fibroblasts from patients with multiple sulphatase deficiency.

7. Steroid sulphatase levels are higher in males than in females of the root vole (Microtus oeconomus). Yet another rodent with an active Y-linked allele?