| Literature DB >> 6948599 |
G Feuerstein, S A Adelberg, I J Kopin, D M Jacobowitz.
Abstract
Prostaglandin E2 (PGE2, 0.5 - 5 nmol/kg) injected into the lateral cerebral ventricle of the rat increased the systemic blood pressure and heart rate in a dose dependent manner. These effects were accompanied by increases in plasma norepinephrine and epinephrine concentration. Injection of low dose of prostaglandin E2 into discrete hypothalamic nuclei induced a marked increase in heart rate, a moderate increase in the arterial blood pressure and a significant elevation of plasma norepinephrine level. This study suggests a possible central role for PGE2 in modulation of cardiovascular dynamics and sympathetic nervous activity.Entities:
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Year: 1982 PMID： 6948599 DOI： 10.1016/0006-8993(82)90370-5
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252