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Literature DB >> 6948557

Alpha 1-Adrenergic stimulation of Ca2+ mobilization without phosphorylase activation in hepatocytes from phosphorylase b kinase-deficient gsd/gsd rats.

Abstract

Phenylephrine, vasopressin and the bivalent cation ionophore A23187 mobilized Ca2+ normally, but failed to activate phosphorylase, in hepatocytes from gsd/gsd rats with a deficiency of liver phosphorylase b kinase. These data provide strong evidence that phosphorylase b kinase is the site of action of the Ca2+ mobilized intracellularly during alpha 1-adrenergic activation of phosphorylase in liver cells.

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Year: 1981 PMID： 6948557 PMCID： PMC1163259 DOI： 10.1042/bj1980379

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

22 in total

1. Heterogeneity of radioligand binding to alpha-adrenergic receptors. Analysis of guanine nucleotide regulation of agonist binding in relation to receptor subtypes.

Authors: B B Hoffman; D Mullikin-Kilpatrick; R J Lefkowitz
Journal: J Biol Chem Date: 1980-05-25 Impact factor: 5.157

2. Calcium movements in in situ mitochondria following activation of alpha-adrenergic receptors in rat liver cells.

Authors: J Poggioli; B Berthon; M Claret
Journal: FEBS Lett Date: 1980-06-30 Impact factor: 4.124

3. Adrenergic receptor of the alpha 1-subtype mediates the activation of the glycogen phosphorylase in normal rat liver.

Authors: M Aggerbeck; G Guellaen; J Hanoune
Journal: Biochem Pharmacol Date: 1980-02-15 Impact factor: 5.858

4. Alpha-adrenergic receptors in liver membranes: delineation with subtype selective radioligands.

Authors: B B Hoffman; D F Dukes; R J Lefkowitz
Journal: Life Sci Date: 1981-01-19 Impact factor: 5.037

5. Liver glycogen synthase in rats with a glycogen-storage disorder. The role of glycogen in the regulation of glycogen synthase.

Authors: C Watts; R S Malthus
Journal: Eur J Biochem Date: 1980

6. Hormonal effects on calcium homeostasis in isolated hepatocytes.

Authors: E Murphy; K Coll; T L Rich; J R Williamson
Journal: J Biol Chem Date: 1980-07-25 Impact factor: 5.157

7. Subclassification of two types of alpha-adrenergic binding sites in rat liver.

Authors: M F El-Refai; J H Exton
Journal: Eur J Pharmacol Date: 1980-03-21 Impact factor: 4.432

8. Effects of trypsin on binding of [3H]epinephrine and [3H]-dihydroergocryptine to rat liver plasma membranes. Evidence for interconversion of binding sites.

Authors: M F El-Refai; J H Exton
Journal: J Biol Chem Date: 1980-06-25 Impact factor: 5.157

9. Glycogen-storage disease in rats, a genetically determined deficiency of liver phosphorylase kinase.

Authors: R Malthus; D G Clark; C Watts; J G Sneyd
Journal: Biochem J Date: 1980-04-15 Impact factor: 3.857

10. Agonist versus antagonist binding to alpha-adrenergic receptors.

Authors: B B Hoffman; T Michel; D M Kilpatrick; R J Lefkowitz; M E Tolbert; H Gilman; J N Fain
Journal: Proc Natl Acad Sci U S A Date: 1980-08 Impact factor: 11.205

5 in total

1. Alpha-adrenergic stimulation of potassium efflux in guinea-pig hepatocytes may involve calcium influx and calcium release.

Authors: L M DeWitt; J W Putney
Journal: J Physiol Date: 1984-01 Impact factor: 5.182

2. Activation of hepatic glycogen phosphorylase b in vivo by sodium sulphate in normal (Wistar) and phosphorylase b kinase-deficient (gsd/gsd) rats.

Authors: G Lutaya; L M Rodrigues; J R Griffiths
Journal: Biochem J Date: 1986-10-15 Impact factor: 3.857