Literature DB >> 6947268

Carbohydrate-specified endocytosis: localization of ligand in the lysosomal compartment.

H B Haimes, R J Stockert, A G Morell, A B Novikoff.   

Abstract

Carbohydrate-directed endocytosis is mediated by a receptor, the hepatic binding protein; it is responsible for the clearance of galactose-terminated glycoproteins from the circulation. This process was investigated by using lactosaminated ferritin which is recognized by this receptor. Ferritin was seen in elements of an extensive "lysosomal compartment" that includes secretory vacuoles, coated vesicles, and GERL. The compartment marked in hepatocytes by the distribution of ligand is similar to that previously described in Kupffer cells (marked by acid phosphatase reaction product and horseradish peroxidase reaction product).

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Year:  1981        PMID： 6947268      PMCID： PMC349167          DOI： 10.1073/pnas.78.11.6936

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

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Authors:  G W Richter
Journal:  Am J Pathol       Date:  1978-05       Impact factor: 4.307

2.  Physical and chemical studies on ceruloplasmin. V. Metabolic studies on sialic acid-free ceruloplasmin in vivo.

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Journal:  J Biol Chem       Date:  1968-01-10       Impact factor: 5.157

3.  Inhibition of 125I-asialofetuin catabolism by leupeptin in the perfused rat liver and in vivo.

Authors:  W A Dunn; J H LaBadie; N N Aronson
Journal:  J Biol Chem       Date:  1979-05-25       Impact factor: 5.157

4.  Antibodies to carbohydrates: preparation of antigens by coupling carbohydrates to proteins by reductive amination with cyanoborohydride.

Authors:  G R Gray
Journal:  Methods Enzymol       Date:  1978       Impact factor: 1.600

5.  Autoradiographic localization of the sites of uptake, cellular transport, and catabolism of low density lipoproteins in the liver of normal and estrogen-treated rats.

Authors:  Y S Chao; A L Jones; G T Hradek; E E Windler; R J Havel
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205

6.  Lysosomal compartment of macrophages: extending the definition of GERL.

Authors:  P M Novikoff; A Yam; A B Novikoff
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

7.  Sites of lipoprotein particles in normal rat hepatocytes.

Authors:  P M Novikoff; A Yam
Journal:  J Cell Biol       Date:  1978-01       Impact factor: 10.539

8.  Glycoprotein catabolism in rat liver: Lysosomal digestion of iodinated asialo-fetuin.

Authors:  J H LaBadie; K P Chapman; N N Aronson
Journal:  Biochem J       Date:  1975-11       Impact factor: 3.857

9.  The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and E.

Authors:  E E Windler; P T Kovanen; Y S Chao; M S Brown; R J Havel; J L Goldstein
Journal:  J Biol Chem       Date:  1980-11-10       Impact factor: 5.157

10.  The galactose-specific recognition system of mammalian liver: the route of ligand internalization in rat hepatocytes.

Authors:  D A Wall; G Wilson; A L Hubbard
Journal:  Cell       Date:  1980-08       Impact factor: 41.582
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  7 in total

1.  Membrane-membrane interactions associated with rapid transfer of liposomal bilirubin to microsomal UDP-glucuronyltransferase. Relevance for hepatocellular transport and biotransformation of hydrophobic substrates.

Authors:  D I Whitmer; P E Russell; J L Gollan
Journal:  Biochem J       Date:  1987-05-15       Impact factor: 3.857

2.  Two populations of prelysosomal structures transporting asialoglycoproteins in rat liver.

Authors:  M T DeBanne; M Bolyos; J Gauldie; E Regoeczi
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

3.  99mTc-neoglycoalbumin (NGA)-binding to human hepatic binding protein (HBP) in vitro.

Authors:  I Virgolini; P Angelberger; C Müller; J O'Grady; H Sinzinger
Journal:  Br J Clin Pharmacol       Date:  1990-02       Impact factor: 4.335

4.  Decreased hepatic function in patients with hepatoma or liver metastasis monitored by a hepatocyte specific galactosylated radioligand.

Authors:  I Virgolini; C Müller; W Klepetko; P Angelberger; H Bergmann; J O'Grady; H Sinzinger
Journal:  Br J Cancer       Date:  1990-06       Impact factor: 7.640

5.  Immunocytochemical localization of lysosomal beta-galactosidase in rat liver.

Authors:  P M Novikoff; N F La Russo; A B Novikoff; R J Stockert; A Yam; G D Le Sage
Journal:  J Cell Biol       Date:  1983-11       Impact factor: 10.539

6.  Effect of colchicine on internalization of prolactin in female rat liver: an in vivo radioautographic study.

Authors:  J J Bergeron; L Resch; R Rachubinski; B A Patel; B I Posner
Journal:  J Cell Biol       Date:  1983-03       Impact factor: 10.539

7.  Concentration of intracellular hepatic apolipoprotein E in Golgi apparatus saccular distensions and endosomes.

Authors:  S Dahan; J P Ahluwalia; L Wong; B I Posner; J J Bergeron
Journal:  J Cell Biol       Date:  1994-12       Impact factor: 10.539
  7 in total

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