Literature DB >> 6946469

Identification, characterization, and distribution of secretin immunoreactivity in rat and pig brain.

T L O'Donohue, C G Charlton, R L Miller, G Boden, D M Jacobowitz.   

Abstract

Secretin immunoreactivity was detected in the central nervous system of the rat and pig with a highly specific radioimmunoassay. The secretin immunoreactivity in the rat and pig brain and duodenum extracts was fractionated by using a reverse-phase high-pressure liquid chromatographic system. The immunoreactive secretin from pig brain and duodenum coeluted precisely with synthetic porcine secretin. However, immunoreactive secretin extracted from rat brain and duodenum eluted slightly before porcine secretin. These data suggest a slight difference in the structure of rat and pig secretin. The detection of secretin in the brain lays the groundwork for studies to determine the role of the peptide in central nervous system function.

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Year:  1981        PMID： 6946469      PMCID： PMC320380          DOI： 10.1073/pnas.78.8.5221

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

1.  Effects of intraduodenal amino acids, fatty acids, and sugars on secretin concentrations.

Authors:  G Boden; N Essa; O E Owen
Journal:  Gastroenterology       Date:  1975-04       Impact factor: 22.682

2.  Gut-type glucagon immunoreactivity in nerves of the rat brain.

Authors:  I Lorén; J Alumets; R Håkanson; F Sundler; J Thorell
Journal:  Histochemistry       Date:  1979-07-11

3.  Secretin-like bioactivity in extracts of porcine brain.

Authors:  V Mutt; M Carlquist; K Tatemoto
Journal:  Life Sci       Date:  1979-11-12       Impact factor: 5.037

4.  The influence of secretin, glucagon and other peptides, of amino acids, prostaglandin endoperoxide analogues and diazepam on the level of adenosine 3',5'-cyclic monophosphate in neuroblastoma x glioma hybrid cells.

Authors:  F Propst; L Moroder; E Wünsch; B Hamprecht
Journal:  J Neurochem       Date:  1979-05       Impact factor: 5.372

5.  Identification and localization of glucagon-related peptides in rat brain.

Authors:  H Tager; M Hohenboken; J Markese; R J Dinerstein
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205

6.  Possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance.

Authors:  M G Bryant; M M Polak; I Modlin; S R Bloom; R H Albuquerque; A G Pearse
Journal:  Lancet       Date:  1976-05-08       Impact factor: 79.321

7.  Effect of rabbit antisecretin serum on postprandial pancreatic secretion in dogs.

Authors:  W Y Chey; M S Kim; K Y Lee; T M Chang
Journal:  Gastroenterology       Date:  1979-12       Impact factor: 22.682

8.  On the biological assay of secretin. The reference standard.

Authors:  J E Jorpes; V Mutt
Journal:  Acta Physiol Scand       Date:  1966-03

9.  Localization and possible function of peptidergic neurons and their interactions with central catecholamine neurons, and the central actions of gut hormones.

Authors:  K Fuxe; K Andersson; T Hökfelt; V Mutt; L Ferland; L F Agnati; D Ganten; S Said; P Eneroth; J A Gustafsson
Journal:  Fed Proc       Date:  1979-08

10.  Regulation by secretin, vasoactive intestinal peptide, and somatostatin of cyclic AMP accumulation in cultured brain cells.

Authors:  D van Calker; M Müller; B Hamprecht
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205
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  16 in total

1.  Central and peripheral administration of secretin inhibits food intake in mice through the activation of the melanocortin system.

Authors:  Carrie Yuen Yee Cheng; Jessica Yan Shuen Chu; Billy Kwok Chong Chow
Journal:  Neuropsychopharmacology       Date:  2010-10-06       Impact factor: 7.853

Review 2.  Brain meets body: the blood-brain barrier as an endocrine interface.

Authors:  William A Banks
Journal:  Endocrinology       Date:  2012-07-09       Impact factor: 4.736

Review 3.  Distribution and Functional Implication of Secretin in Multiple Brain Regions.

Authors:  Ruanna Wang; Billy K C Chow; Li Zhang
Journal:  J Mol Neurosci       Date:  2018-06-07       Impact factor: 3.444

4.  Secretin: structure of the precursor and tissue distribution of the mRNA.

Authors:  A S Kopin; M B Wheeler; A B Leiter
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

5.  The knockout of secretin in cerebellar Purkinje cells impairs mouse motor coordination and motor learning.

Authors:  Li Zhang; Sookja Kim Chung; Billy Kwok Chong Chow
Journal:  Neuropsychopharmacology       Date:  2013-12-19       Impact factor: 7.853

6.  Processing of prosecretin: isolation of a secretin precursor from porcine intestine.

Authors:  G Gafvelin; H Jörnvall; V Mutt
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

Review 7.  Class II G protein-coupled receptors and their ligands in neuronal function and protection.

Authors:  Bronwen Martin; Rakel Lopez de Maturana; Randall Brenneman; Tom Walent; Mark P Mattson; Stuart Maudsley
Journal:  Neuromolecular Med       Date:  2005       Impact factor: 3.843

8.  Identification of glucagon receptors in rat brain.

Authors:  N M Hoosein; R S Gurd
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

9.  Secretin: hypothalamic distribution and hypothesized neuroregulatory role in autism.

Authors:  M G Welch; J D Keune; T B Welch-Horan; N Anwar; M Anwar; R J Ludwig; D A Ruggiero
Journal:  Cell Mol Neurobiol       Date:  2004-04       Impact factor: 5.046

10.  Secretin and vasoactive intestinal peptide acutely increase tyrosine 3-monooxygenase in the rat superior cervical ganglion.

Authors:  N Y Ip; C K Ho; R E Zigmond
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205
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