Bilateral nasal squamous carcinoma arising in papillomatosis: report of a case developing after chemotherapy for leukemia.

A patient with a 25-year history of recurrent left nasal polyps is described. Recurrent papillomatosis (schneiderian or inverted papilloma) involving the left nasal cavity had been histologically documented for five years. Following the onset of and chemotherapy for acute myelomonocytic leukemia, the patient developed papillomatosis in the right nasal cavity and invasive squamous cell carcinomas in both nasal cavities. The case may represent the first reported example of apparently separate invasive carcinomas arising in nasal papillomatosis and developing in both the left and right nasal cavities.