Literature DB >> 694530

Cocaine plasma concentration: relation to physiological and subjective effects in humans.

J I Javaid, M W Fischman, C R Schuster, H Dekirmenjian, J M Davis.   

Abstract

Volunteer subjects with previous histories of cocaine use were administered cocaine hydrochloride intravenously or intranasally. There was a positive relationship between peak plasma concentration, physiological and subjective responses, and dose administered. The rate of cocaine disappearance after intravenous administration paralleled the drop in physiological and subjective drug effects. After intranasal administration, blood levels remained elevated for a considerably longer period.

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Year:  1978        PMID： 694530     DOI： 10.1126/science.694530

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  53 in total

1.  Impact of self-administered cocaine and cocaine cues on extracellular dopamine in mesolimbic and sensorimotor striatum in rhesus monkeys.

Authors:  C W Bradberry; R L Barrett-Larimore; P Jatlow; S R Rubino
Journal:  J Neurosci       Date:  2000-05-15       Impact factor: 6.167

2.  Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use.

Authors:  C W Bradberry
Journal:  J Neurosci       Date:  2000-09-15       Impact factor: 6.167

3.  Influence of acute bupropion pre-treatment on the effects of intranasal cocaine.

Authors:  William W Stoops; Joshua A Lile; Paul E A Glaser; Lon R Hays; Craig R Rush
Journal:  Addiction       Date:  2012-02-11       Impact factor: 6.526

4.  Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys.

Authors:  Gregory T Collins; Remy L Brim; Kathleen R Noon; Diwahar Narasimhan; Nicholas W Lukacs; Roger K Sunahara; James H Woods; Mei-Chuan Ko
Journal:  J Pharmacol Exp Ther       Date:  2012-04-19       Impact factor: 4.030

Review 5.  Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: focus on dopamine, norepinephrine and glutamate.

Authors:  Colin N Haile; James J Mahoney; Thomas F Newton; Richard De La Garza
Journal:  Pharmacol Ther       Date:  2012-01-31       Impact factor: 12.310

6.  EVALUATION OF DRUG ABUSE TREATMENT MEDICATIONS: CONCORDANCE BETWEEN CLINICAL AND PRECLINICAL STUDIES.

Authors:  N K Mello
Journal:  NIDA Res Monogr       Date:  2005-05

7.  Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase.

Authors:  Gregory T Collins; Kathy A Carey; Diwahar Narasimhan; Joseph Nichols; Aaron A Berlin; Nicholas W Lukacs; Roger K Sunahara; James H Woods; Mei-Chuan Ko
Journal:  Neuropsychopharmacology       Date:  2011-02-02       Impact factor: 7.853

8.  Concurrent cocaine-ethanol ingestion in humans: pharmacology, physiology, behavior, and the role of cocaethylene.

Authors:  E F McCance-Katz; L H Price; C J McDougle; T R Kosten; J E Black; P I Jatlow
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

9.  Acute behavioral and cardiac effects of cocaine and alcohol combinations in humans.

Authors:  S T Higgins; C R Rush; W K Bickel; J R Hughes; M Lynn; M A Capeless
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

10.  Varying the rate of intravenous cocaine infusion influences the temporal dynamics of both drug and dopamine concentrations in the striatum.

Authors:  Ellie-Anna Minogianis; Waqqas M Shams; Omar S Mabrouk; Jenny-Marie T Wong; Wayne G Brake; Robert T Kennedy; Patrick du Souich; Anne-Noël Samaha
Journal:  Eur J Neurosci       Date:  2018-07-24       Impact factor: 3.386
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