Familial osteogenic sarcoma occurring in pagetoid bone.

In a father and son who had familial Paget's disease of bone, secondary osteogenic sarcomas involving identical anatomic sites developed at about the same age. A review of the literature revealed 35 additional cases of familial osteogenic sarcoma arising in 14 families, mainly among siblings. The relationship of osteogenic sarcoma to Paget's disease and the familial aspects of both conditions are discussed. This is the first recorded instance of a vertical male-to-male transmission of Paget's disease and osteosarcoma.