Literature DB >> 6941044

Soft-tissue necrosis induced by extravasated cancer chemotherapeutic agents.

R D Barr, S G Benton, L W Belbeck.   

Abstract

The inadvertent extravasation of anticancer drugs in clinical use may result in the development of indolent lesions at the site of injection. Investigation of this phenomenon in Hartley guinea pigs showed that the pathogenesis was based on direct tissue toxicity and not on sensitization. The risk of a serious reaction appeared to be related to the localization of the injurious agent within the dermis rather than at the subcutaneous site.

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Year:  1981        PMID： 6941044     DOI： 10.1093/jnci/66.6.1129

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  5 in total

1.  Prevention of tissue necrosis due to accidental extravasation of cytostatic drugs by a conservative approach.

Authors:  N B Tsavaris; P Komitsopoulou; P Karagiaouris; P Loukatou; I Tzannou; N Mylonakis; P Kosmidis
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

2.  Extravasation injury potential of CI-980, a novel synthetic mitotic inhibitor.

Authors:  J R MacDonald; D G Pegg
Journal:  Cancer Chemother Pharmacol       Date:  1993       Impact factor: 3.333

3.  Dose-dependent skin ulcers in mice treated with DNA binding antitumor antibiotics.

Authors:  M J Soble; R T Dorr; P Plezia; S Breckenridge
Journal:  Cancer Chemother Pharmacol       Date:  1987       Impact factor: 3.333

4.  Intralesional injection of mitomycin C at transurethral incision of bladder neck contracture may offer limited benefit: TURNS Study Group.

Authors:  Jeffrey D Redshaw; Joshua A Broghammer; Thomas G Smith; Bryan B Voelzke; Bradley A Erickson; Christopher D McClung; Sean P Elliott; Nejd F Alsikafi; Angela P Presson; Michael E Aberger; James R Craig; William O Brant; Jeremy B Myers
Journal:  J Urol       Date:  2014-09-06       Impact factor: 7.450

5.  Soft-tissue injury caused by antineoplastic drugs is inhibited by topical dimethyl sulphoxide and alpha tocopherol.

Authors:  P Nobbs; R D Barr
Journal:  Br J Cancer       Date:  1983-12       Impact factor: 7.640
  5 in total

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