Literature DB >> 6940134

Transforming activity of human tumor DNAs.

T G Krontiris, G M Cooper.   

Abstract

High molecular weight DNAs of 26 human tumors and tumor cell lines were assayed for the presence of transmissible activated transforming genes by transfection of NIH 3T3 mouse cells. DNAs of two bladder carcinoma cell lines induced transformation with high efficiencies (approximately 0.2 transformant per microgram of DNA), whereas DNAs of the other tumors studied lacked detectable transforming activity. These findings suggest that dominant mutations or gene rearrangements can result in the activation of cellular transforming genes in some human tumors.

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Year:  1981        PMID： 6940134      PMCID： PMC319971          DOI： 10.1073/pnas.78.2.1181

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

1.  Transformation of NIH/3T3 mouse cells by DNA of Rous sarcoma virus.

Authors:  N G Copeland; A D Zelenetz; G M Cooper
Journal:  Cell       Date:  1979-08       Impact factor: 41.582

2.  Characterisation of human cell lines and differentiation from HeLa by enzyme typing.

Authors:  S Povey; D A Hopkinson; H Harris; L M Franks
Journal:  Nature       Date:  1976-11-04       Impact factor: 49.962

3.  Measurements of the molecular size of the simian virus 40 large T antigen.

Authors:  J D Griffin; S Light; D M Livingston
Journal:  J Virol       Date:  1978-07       Impact factor: 5.103

4.  Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin.

Authors:  C Shih; B Z Shilo; M P Goldfarb; A Dannenberg; R A Weinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

5.  Epstein-Barr virus-associated complement-fixing and nuclear antigens in Burkitt lymphoma biopsies.

Authors:  B M Reedman; G Klein; J H Pope; M K Walters; J Hilgers; S Singh; B Johansson
Journal:  Int J Cancer       Date:  1974-06-15       Impact factor: 7.396

6.  Cell cycles in two cell lines of human bladder carcinoma.

Authors:  T Kato; R J Irwin; G R Prout
Journal:  Tohoku J Exp Med       Date:  1977-02       Impact factor: 1.848

7.  Markers of neoplastic transformation in epithelial cell lines derived from human carcinomas.

Authors:  C J Marshall; L M Franks; A W Carbonell
Journal:  J Natl Cancer Inst       Date:  1977-06       Impact factor: 13.506

8.  Transforming genes of neoplasms induced by avian lymphoid leukosis viruses.

Authors:  G M Cooper; P E Neiman
Journal:  Nature       Date:  1980-10-16       Impact factor: 49.962

9.  Transforming activity of DNA of chemically transformed and normal cells.

Authors:  G M Cooper; S Okenquist; L Silverman
Journal:  Nature       Date:  1980-04-03       Impact factor: 49.962

10.  Ultrastructure, karyology and immunology of a cell line originated from a human transitional-cell carcinoma.

Authors:  C O'Toole; Z H Price; Y Ohnuki; B Unsgaard
Journal:  Br J Cancer       Date:  1978-07       Impact factor: 7.640
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  91 in total

Review 1.  Human herpesvirus 6.

Authors:  D K Braun; G Dominguez; P E Pellett
Journal:  Clin Microbiol Rev       Date:  1997-07       Impact factor: 26.132

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Authors:  M Demaria; S Misale; C Giorgi; V Miano; A Camporeale; J Campisi; P Pinton; V Poli
Journal:  Cell Death Differ       Date:  2012-03-09       Impact factor: 15.828

3.  Metaplastic change in mesenchymal stem cells induced by activated ras oncogene.

Authors:  C Y Tzen; M Filipak; R E Scott
Journal:  Am J Pathol       Date:  1990-11       Impact factor: 4.307

Review 4.  MicroRNA-Based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer.

Authors:  Sriganesh B Sharma; John Michael Ruppert
Journal:  Drug Dev Res       Date:  2015-08-18       Impact factor: 4.360

Review 5.  Following the cytokine signaling pathway to leukemogenesis: a chronology.

Authors:  Kendall A Smith; James D Griffin
Journal:  J Clin Invest       Date:  2008-11       Impact factor: 14.808

6.  DNA transfer of focus- and tumor-forming ability into nontumorigenic CHEF cells.

Authors:  B L Smith; A Anisowicz; L A Chodosh; R Sager
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

7.  Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells.

Authors:  S Pulciani; E Santos; A V Lauver; L K Long; K C Robbins; M Barbacid
Journal:  Proc Natl Acad Sci U S A       Date:  1982-05       Impact factor: 11.205

8.  In vivo horizontal oncogenesis by a human tumor in nude mice.

Authors:  D M Goldenberg; R A Pavia
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

9.  Correlation of individual papilloma latency time with DNA adducts, 8-hydroxy-2'-deoxyguanosine, and the rate of DNA synthesis in the epidermis of mice treated with 7,12-dimethylbenz[alpha]anthracene.

Authors:  W H Fischer; W K Lutz
Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-20       Impact factor: 11.205

10.  Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors.

Authors:  R L Brinster; H Y Chen; A Messing; T van Dyke; A J Levine; R D Palmiter
Journal:  Cell       Date:  1984-06       Impact factor: 41.582
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