| Literature DB >> 6940056 |
R L Barbieri, R Osathanondh, K J Ryan.
Abstract
In human corpus luteum (CL) microsomes, danazol inhibited 3 beta-hydroxysteroid dehydrogenase, 17,20-lyase, 17 alpha-hydroxylase, and 17 beta-hydroxysteroid dehydrogenase enzymes. Danazol did not inhibit aromatase. The observation that danazol can directly inhibit multiple enzymes of CL steroidogenesis may provide a molecular basis for explaining previous reports that danazol inhibits CL steroidogenesis in the monkey in vivo.Entities:
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Year: 1981 PMID： 6940056
Source DB: PubMed Journal: Obstet Gynecol ISSN： 0029-7844 Impact factor: 7.661