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Literature DB >> 6939451

Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid.

Abstract

The recent finding that retinoic acid induces terminal granulocytic differentiation of the human promyelocytic leukemia cell line, HL-60, prompted an investigation of the sensitivity to this inducer of human myelocytic leukemia cells in primary suspension culture. Of the 21 leukemic specimens, only cells from the two patients with acute promyelocytic leukemia differentiated in response to retinoic acid. After an incubation period of 5--7 days in 1 microM retinoic acid, the cells from these two patients showed extensive morphological and functional maturation. Thus, because it appears that retinoic acid specifically induces granulocytic differentiation of leukemic promyelocytes, this compound may have therapeutic utility in the treatment of acute promyelocytic leukemia.

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Year: 1981 PMID： 6939451

Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113

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Cited

90 in total

1. Retinoid X receptor (RXR) agonist-induced activation of dominant-negative RXR-retinoic acid receptor alpha403 heterodimers is developmentally regulated during myeloid differentiation.

Authors: B S Johnson; R A Chandraratna; R A Heyman; E A Allegretto; L Mueller; S J Collins
Journal: Mol Cell Biol Date: 1999-05 Impact factor: 4.272

2. Localization of the cellular retinoic acid binding protein (CRABP) gene relative to the acute promyelocytic leukemia-associated breakpoint on human chromosome 15.

Authors: A Geurts van Kessel; H de Leeuw; E J Dekker; L Rijks; N Spurr; D Ledbetter; E Kootwijk; M J Vaessen
Journal: Hum Genet Date: 1991-06 Impact factor: 4.132

3. Direct effects of 13-cis and all-trans retinoic acid on normal bone marrow (BM) progenitors: comparative study on BM mononuclear cells and on isolated CD34+ BM cells.

Authors: D R van Bockstaele; M Lenjou; H W Snoeck; F Lardon; P Stryckmans; M E Peetermans
Journal: Ann Hematol Date: 1993-02 Impact factor: 3.673

4. Differential expression of the amv gene in human hematopoietic cells.

Authors: E H Westin; R C Gallo; S K Arya; A Eva; L M Souza; M A Baluda; S A Aaronson; F Wong-Staal
Journal: Proc Natl Acad Sci U S A Date: 1982-04 Impact factor: 11.205

5. Clinical aspects of acute myeloid leukemias of the FAB types M3 and M4Eo. The AML Cooperative Group.

Authors: T Haferlach; W Gassmann; H Löffler; C Jürgensen; J Noak; W D Ludwig; E Thiel; D Haase; C Fonatsch; R Becher
Journal: Ann Hematol Date: 1993-04 Impact factor: 3.673

6. Antiproliferative effect of 13-cis-retinoic acid is associated with granulocyte differentiation and decrease in cyclin B1 and Bcl-2 protein levels in G0/G1 arrested HL-60 cells.

Authors: Ana Vuletic; Gordana Konjevic; Desanka Milanovic; Sabera Ruzdijic; Vladimir Jurisic
Journal: Pathol Oncol Res Date: 2010-01-19 Impact factor: 3.201

7. Changes in tyrosine-phosphorylated p190 and its association with p120 type I and p100 type II rasGAPs during myelomonocytic differentiation of human leukemic cells.

Authors: J C Cheng; A R Frackelton; E L Bearer; P S Kumar; B Kannan; A Santos-Moore; A Rifai; J Settleman; J W Clark
Journal: Cell Growth Differ Date: 1995-02