[The influence of 6-mercaptopurine on the humoral immune response in guinea pig. 2. The influence on formation of complement binding antibodies (author's transl)].

The effectivity of treatment with 10 mg 6-mercaptopurine/kg/day--beginning on the day of antigen injection and continuing for seven days--on the synthesis of complement binding antibodies is very different. The formation of gamma-2-antibodies against BGG was nearly complete suppressed, an influence on the anti-DNP-gamma-2-antibody formation was not detectable and the antibody formation against HSA was enhanced. The results suggest that the kind of antigen is very important for the immunosuppressive activity of 6-mercaptopurine in guinea pigs.