Literature DB >> 6935493

Kynurenine hydroxylase mutants of the nematode Caenorhabditis elegans.

S S Siddiqui, P Babu.   

Abstract

The relation of intestinal autofluorescence to tryptophan catabolism in the free-living nematode Caenorhabditis elegans has been investigated. L-Kynurenine hydroxylase (EC 1.14.13.9) activity has been detected in normal (wild-type) individuals. Mutants in the gene flu-1 which are characterized by an altered autofluorescence of the intestine cells, i.e., more intense than wild type and bluish purple instead of light blue have also been examined. They show a markedly reduced activity of kynurenine hydroxylase. The finding supports the previously proposed model for altered fluorescence based on chromatographic identification of tryptophan catabolites present.

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Year:  1980        PMID： 6935493     DOI： 10.1007/bf00268441

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  8 in total

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Journal:  Genetics       Date:  1979-01       Impact factor: 4.562

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Authors:  J E Sulston; H R Horvitz
Journal:  Dev Biol       Date:  1977-03       Impact factor: 3.582

6.  Developmental and genetic studies on kynurenine hydroxylase from Drosophila melanogaster.

Authors:  D T Sullivan; R J Kitos; M C Sullivan
Journal:  Genetics       Date:  1973-12       Impact factor: 4.562

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Authors:  D Ghosh; H S Forrest
Journal:  Genetics       Date:  1967-03       Impact factor: 4.562

8.  The genetics of Caenorhabditis elegans.

Authors:  S Brenner
Journal:  Genetics       Date:  1974-05       Impact factor: 4.562
  8 in total
  10 in total

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4.  Mutagen sensitivity of kynureninase mutants of the nematode Caenorhabditis elegans.

Authors:  S G Bhat; P Babu
Journal:  Mol Gen Genet       Date:  1980

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10.  The mysterious case of the C. elegans gut granule: death fluorescence, anthranilic acid and the kynurenine pathway.

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  10 in total

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