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Literature DB >> 6934796

Plasma kinetics and urinary excretion of primaquine in man.

J Greaves, D A Evans, H M Gilles, K A Fletcher, D Bunnag, T Harinasuta.

Abstract

1 The kinetics of primaquine have been studied in twenty volunteers after single and multiple dose regimes. 2 The kinetic parameters were similar in glucose-6-phosphate dehydrogenase (G6PD) normal Thais, G6PD deficient Thais and in Caucasians. 3 The Caucasian subjects showed about 1% of the dose was excreted in the urine. 4 The kinetic parameters obtained from multiple dose studies in Thais were very similar to those obtained from single dose studies in Thais.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Primaquine

Year: 1980 PMID： 6934796 PMCID： PMC1430082 DOI： 10.1111/j.1365-2125.1980.tb01777.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

5 in total

1. STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS. VIII. THE PHYSIOLOGICAL DISPOSITION OF PAMAQUINE.

Authors: C G Zubrod; T J Kennedy; J A Shannon
Journal: J Clin Invest Date: 1948-05 Impact factor: 14.808

Review 2. Drug-induced hemolytic anemia.

Authors: E Beutler
Journal: Pharmacol Rev Date: 1969-03 Impact factor: 25.468

3. The search for new antimalarial drugs.

Authors: R E Strube
Journal: J Trop Med Hyg Date: 1975-08

4. The metabolism of chloroquine in man during and after repeated oral dosage.

Authors: E W McChesney; M J Fasco; W F Banks
Journal: J Pharmacol Exp Ther Date: 1967-11 Impact factor: 4.030

5. A selected ion monitoring assay for primaquine in plasma and urine.

Authors: J Greaves; D A Price-Evans; H M Gilles; J D Baty
Journal: Biomed Mass Spectrom Date: 1979-03

5 in total

14 in total

Review 1. Ethnic differences in drug metabolism.

Authors: W Kalow
Journal: Clin Pharmacokinet Date: 1982 Sep-Oct Impact factor: 6.447

2. Pharmacokinetics of primaquine in man. II. Comparison of acute vs chronic dosage in Thai subjects.

Authors: S A Ward; G W Mihaly; G Edwards; S Looareesuwan; R E Phillips; P Chanthavanich; D A Warrell; M L Orme; A M Breckenridge
Journal: Br J Clin Pharmacol Date: 1985-06 Impact factor: 4.335

Review 3. Prevention of malaria.

Authors: J S Keystone
Journal: Drugs Date: 1990-03 Impact factor: 9.546

Review 9. Antiparasitic drugs in children.

Authors: N J White
Journal: Clin Pharmacokinet Date: 1989 Impact factor: 6.447

10. Pharmacokinetics of primaquine in man. I. Studies of the absolute bioavailability and effects of dose size.

Authors: G W Mihaly; S A Ward; G Edwards; D D Nicholl; M L Orme; A M Breckenridge
Journal: Br J Clin Pharmacol Date: 1985-06 Impact factor: 4.335

Plasma kinetics and urinary excretion of primaquine in man.

1. STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS. VIII. THE PHYSIOLOGICAL DISPOSITION OF PAMAQUINE.

Review 2. Drug-induced hemolytic anemia.

3. The search for new antimalarial drugs.

4. The metabolism of chloroquine in man during and after repeated oral dosage.

5. A selected ion monitoring assay for primaquine in plasma and urine.

Review 1. Ethnic differences in drug metabolism.

2. Pharmacokinetics of primaquine in man. II. Comparison of acute vs chronic dosage in Thai subjects.

Review 3. Prevention of malaria.

Review 4. Clinical pharmacokinetics of antimalarial drugs.

5. Studies on the pharmacokinetics of primaquine.

6. Pharmacokinetics of primaquine in man: identification of the carboxylic acid derivative as a major plasma metabolite.

7. Pharmacokinetics of primaquine in patients with P. vivax malaria.

Review 8. Clinical features and management of poisoning due to antimalarial drugs.

Review 9. Antiparasitic drugs in children.

10. Pharmacokinetics of primaquine in man. I. Studies of the absolute bioavailability and effects of dose size.