Literature DB >> 6934514

Studies on the active center of D- and L-lactate dehydrogenases using oxamate-diaminohexyl-Sepharose affinity chromatography.

P Tuengler, T N Stein, G L Long.   

Abstract

Vertebrate and invertebrate L-lactate dehydrogenases (L-lactate:NAD+ oxidoreductase, EC 1.1.1.27) are effectively bound to oxamate-diaminohexyl-Sepharose, whereas several D-lactate dehydrogenases (D-lactate:NAD+ oxidoreductase, EC 1.1.1.28) do not bind to the same Sepharose. One explanation for our findings is that the enzymes' substrate is oriented in a reversed manner in the active center of the D- and L-lactate dehydrogenases.

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Year:  1980        PMID： 6934514      PMCID： PMC350165          DOI： 10.1073/pnas.77.10.5832

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

1.  THE COMPARATIVE ENZYMOLOGY OF LACTIC DEHYDROGENASES. I. PROPERTIES OF THE CRYSTALLINE BEEF AND CHICKEN ENZYMES.

Authors:  A PESCE; R H MCKAY; F STOLZENBACH; R D CAHN; N O KAPLAN
Journal:  J Biol Chem       Date:  1964-06       Impact factor: 5.157

2.  Structural adaptations of lactate dehydrogenase isozymes.

Authors:  W Eventoff; M G Rossmann; S S Taylor; H J Torff; H Meyer; W Keil; H H Kiltz
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

3.  Catalytic properties of lactate dehydrogenase in Homarus americanus.

Authors:  R D Eichner; N O Kaplan
Journal:  Arch Biochem Biophys       Date:  1977-06       Impact factor: 4.013

4.  Combined coenzyme-substrate analogues of various dehydrogenases. Synthesis of (3S)- and (3R)-5-(3-carboxy-3-hydroxypropyl)nicotinamide adenine dinucleotide and their interaction with (S)- and (R)-lactate-specific dehydrogenases.

Authors:  U Grau; H Kapmeyer; W E Trommer
Journal:  Biochemistry       Date:  1978-10-31       Impact factor: 3.162

5.  Functional anion binding sites in dogfish M4 lactate dehydrogenase.

Authors:  M J Adams; A Liljas; M G Rossman
Journal:  J Mol Biol       Date:  1973-06-05       Impact factor: 5.469

6.  Diphosphopyridine nucleotide-linked D-lactate dehydrogenases from the horseshoe crab, Limulus polyphemus and the seaworm, Nereis virens. I. Physical and chemical properties.

Authors:  G L Long; N O Kaplan
Journal:  Arch Biochem Biophys       Date:  1973-02       Impact factor: 4.013

7.  Diphosphopyridine nucleotide-linked D-lactate dehydrogenases from the horseshoe crab, Limulus polyphemus, and the seaworm, Nereis virens. II. Catalytic properties.

Authors:  G L Long; N O Kaplan
Journal:  Arch Biochem Biophys       Date:  1973-02       Impact factor: 4.013

8.  Substrate and product inhibition of rabbit muscle lactic dehydrogenase heart (H4) and muscle (M4) isozymes.

Authors:  R Stambaugh; D Post
Journal:  J Biol Chem       Date:  1966-04-10       Impact factor: 5.157

9.  The separation of lactate dehydrogenase X from other lactate dehydrogenase isozymes of mouse testes by affinity chromatography.

Authors:  H Spielmann; R P Erickson; C J Epstein
Journal:  FEBS Lett       Date:  1973-09-01       Impact factor: 4.124

10.  Physical and chemical properties of lactate dehydrogenase in Homarus americanus.

Authors:  R D Eichner; N O Kaplan
Journal:  Arch Biochem Biophys       Date:  1977-06       Impact factor: 4.013
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  2 in total

1.  D-lactate dehydrogenase. Substrate specificity and use as a catalyst in the synthesis of homochiral 2-hydroxy acids.

Authors:  E S Simon; R Plante; G M Whitesides
Journal:  Appl Biochem Biotechnol       Date:  1989-11       Impact factor: 2.926

2.  Insights into the stereospecificity of the d-specific dehalogenase from Rhizobium sp. RC1 toward d- and l-2-chloropropionate.

Authors:  Ismaila Yada Sudi; Azzmer Azzar Abdul Hamid; Mohd Shahir Shamsir; Haryati Jamaluddin; Roswanira Abdul Wahab; Fahrul Huyop
Journal:  Biotechnol Biotechnol Equip       Date:  2014-10-23       Impact factor: 1.632
  2 in total

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