Literature DB >> 6933493

Uptake of free choline by isolated perfused rat liver.

S H Zeisel, D L Story, R J Wurtman, H Brunengraber.   

Abstract

The uptake of free choline by isolated perfused rat liver was characterized. A saturable uptake mechanism [Ka = 0.17 +/- 0.07 mM (SD); Vmax = 0.84 +/- 0.16 mumol/min X g dry weight] and a nonsaturable mechanism (through which uptake is proportional to choline concentration in the perfusate) were identified. Most of the choline transported into hepatocytes was converted to betaine, phosphorylcholine, or lecithin. Free choline also accumulated within the intracellular space, suggesting that choline oxidase activity does not always limit choline's uptake by the liver.

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Year:  1980        PMID： 6933493      PMCID： PMC349854          DOI： 10.1073/pnas.77.8.4417

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Distribution and metabolism of intravenously administered choline[methyl- 3-H] and synthesis in vivo of acetylcholine in various tissues of guinea pigs.

Authors:  D R Haubrich; P F Wang; P W Wedeking
Journal:  J Pharmacol Exp Ther       Date:  1975-04       Impact factor: 4.030

2.  Comparison of perfusates in the study of choline uptake by isolated rat livers.

Authors:  D J Tuma; M F Sorrell; A J Barak
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1973-07

3.  Possible interrelationship of ethanol metabolism and choline oxidation in the liver.

Authors:  D J Tuma; A J Barak; D F Schafer; M F Sorrell
Journal:  Can J Biochem       Date:  1973-02

4.  Fatty acid and 3- -hydroxysterol synthesis in the perfused rat liver. Including measurements on the production of lactate, pyruvate, -hydroxy-butyrate, and acetoacetate by the fed liver.

Authors:  H Brunengraber; M Boutry; J M Lowenstein
Journal:  J Biol Chem       Date:  1973-04-25       Impact factor: 5.157

5.  The determination of picomole amounts of acetylcholine in mammalian brain.

Authors:  A M Goldberg; R E McCaman
Journal:  J Neurochem       Date:  1973-01       Impact factor: 5.372

6.  Uptake of choline by the isolated perfused rat liver.

Authors:  D J Tuma; H C Beckenhauer; R C Keefer; A J Barak
Journal:  Can J Physiol Pharmacol       Date:  1970-01       Impact factor: 2.273

7.  Electrophoresis of acetylcholine, choline and related compounds.

Authors:  L T Potter; W Murphy
Journal:  Biochem Pharmacol       Date:  1967-07-07       Impact factor: 5.858

8.  In vivo studies on pathways for the biosynthesis of lecithin in the rat.

Authors:  P Bjørnstad; J Bremer
Journal:  J Lipid Res       Date:  1966-01       Impact factor: 5.922

9.  Activity and intracellular distribution of enzymes of ketone-body metabolism in rat liver.

Authors:  D H Williamson; M W Bates; H A Krebs
Journal:  Biochem J       Date:  1968-07       Impact factor: 3.857

10.  The control of the plasma choline concentration in the cat.

Authors:  J E Gardiner; W D Paton
Journal:  J Physiol       Date:  1972-12       Impact factor: 5.182
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  12 in total

1.  Tight connection between choline transport and phosphatidylcholine synthesis in MDCK cells.

Authors:  P Zlatkine; C Leroy; G Moll; C Le Grimellec
Journal:  Biochem J       Date:  1996-05-01       Impact factor: 3.857

2.  Transport and metabolism of radiolabeled choline in hepatocellular carcinoma.

Authors:  Yu Kuang; Nicolas Salem; David J Corn; Bernadette Erokwu; Haibin Tian; Fangjing Wang; Zhenghong Lee
Journal:  Mol Pharm       Date:  2010-09-21       Impact factor: 4.939

3.  Radioactive choline metabolism in guinea pig gallbladder. Is there measurable acetylcholine release?

Authors:  E A Brotschi; C L Hilbinger; E A Kahl; W A Vaules; N A Midis; J K Blusztajn; S H Zeisel
Journal:  Dig Dis Sci       Date:  1995-09       Impact factor: 3.199

4.  Choline accumulation in isolated rat hepatocytes.

Authors:  K Yoshioka; H Nishimura
Journal:  Experientia       Date:  1988-10-15

5.  The phorbol ester 12-0-tetradecanoyl-phorbol-13-acetate and stimulation of 3H-choline incorporation into endoplasmic reticulum membranes and other subcellular fractions of Krebs II ascites cells during in vitro incubation.

Authors:  A Fjose; I F Pryme; J R Lillehaug
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396

6.  Uptake of choline by rat mammary-gland epithelial cells.

Authors:  C K Chao; E A Pomfret; S H Zeisel
Journal:  Biochem J       Date:  1988-08-15       Impact factor: 3.857

7.  Choline metabolism and phosphatidylcholine biosynthesis in cultured rat hepatocytes.

Authors:  P H Pritchard; D E Vance
Journal:  Biochem J       Date:  1981-04-15       Impact factor: 3.857

8.  Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial.

Authors:  Carol L Cheatham; Barbara Davis Goldman; Leslie M Fischer; Kerry-Ann da Costa; J Steven Reznick; Steven H Zeisel
Journal:  Am J Clin Nutr       Date:  2012-11-07       Impact factor: 7.045

9.  Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.

Authors:  David A Horita; Sunil Hwang; Julie M Stegall; Walter B Friday; David R Kirchner; Steven H Zeisel
Journal:  Am J Clin Nutr       Date:  2021-06-01       Impact factor: 7.045

Review 10.  Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss.

Authors:  Teresa Partearroyo; Néstor Vallecillo; María A Pajares; Gregorio Varela-Moreiras; Isabel Varela-Nieto
Journal:  Front Mol Neurosci       Date:  2017-04-25       Impact factor: 5.639
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