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Literature DB >> 6933475

Genetic control of murine IgD structural heterogeneity.

Abstract

Murine B lymphocytes express two native forms of surface IgD: IgDI consists of two delta heavy chains and two light chains; IgDII consists of one heavy chain and one light chain. The relative amounts of IgDI and IgDII present on spleen cells were found to vary significantly among different strains of mice. Genetic evidence demonstrated that the IgDI/IgDII ratio is linked to the Igh-5 allotype. (The delta heavy chain is the product of the Igh-5 locus). Mice bearing the Igh-5e allotype have a low ratio, and mice bearing the Igh-5a or Igh-5b allotype have a high ratio. The Igh-5 locus and the gene controlling the IgDI/IgDII ratio appear to map to the region between the Igh-6 and Igh-V loci.

Entities: Gene Species

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Year: 1980 PMID： 6933475 PMCID： PMC349811 DOI： 10.1073/pnas.77.7.4256

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

11 in total

2. H-40, an antigen controlled by an Igh linked gene and recognized by cytotoxic T lymphocytes. I. Genetic analysis of H-40 and distribution of its product on B cell tumors.

Authors: J Forman; R Riblet; K Brooks; E S Vitetta; L A Henderson
Journal: J Exp Med Date: 1984-06-01 Impact factor: 14.307

2 in total

Genetic control of murine IgD structural heterogeneity.

Review 1. Allotypes of IgM and IgD receptors in the mouse: a probe for lymphocyte differentiation.

2. IgD is present on the cell surface of murine lymphocytes in two forms: delta 2L2 and delta L.

3. Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens.

4. Candidate for immunoglobulin D present on murine B lymphocytes.

5. Murine cell surface immunoglobulin: two forms of delta-heavy chain.

6. Characterization of IgD. II. Molecular forms of IgD in human B cells.

7. Genetic polymorphism of IgD-like cell surface immunoglobulin in the mouse.

8. A myeloma hybrid producing antibody specific for an allotypic determinant on "IgD-like" molecules of the mouse.

9. Cell surface immunoglobulin. X. Identification of an IgD-like molecule on the surface of murine splenocytes.

10. Cell surface immunoglobulin. II. Isolation and characterization of immunoglobulin from mouse splenic lymphocytes.

1. Recognition of an Igh-linked histocompatibility antigen, H-40, on B-cell tumors by cytotoxic T lymphocytes.

2. H-40, an antigen controlled by an Igh linked gene and recognized by cytotoxic T lymphocytes. I. Genetic analysis of H-40 and distribution of its product on B cell tumors.