Literature DB >> 6931123

Hypothiocyanite ion: detection of the antimicrobial agent in human saliva.

E L Thomas, K P Bates, M M Jefferson.   

Abstract

The median concentration of hypothiocyanite (OSCN-) in freshly collected whole saliva was 10 microM. The OSCN- concentration increased to a median value of 36 microM during incubation for one h at 37 degrees in vitro. This increase was partially inhibited by adding certain sugars (especially sucrose). The results suggest that OSCN- is a naturally occurring component of human saliva. Also, dietary carbohydrate may inhibit OSCN- accumulation and antimicrobial action in saliva.

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Year:  1980        PMID： 6931123     DOI： 10.1177/00220345800590090201

Source DB:  PubMed          Journal:  J Dent Res        ISSN： 0022-0345            Impact factor:   6.116


  14 in total

1.  Antibacterial effect of lactoperoxidase and myeloperoxidase against Bacillus cereus.

Authors:  J Tenovuo; K K Mäkinen; G Sievers
Journal:  Antimicrob Agents Chemother       Date:  1985-01       Impact factor: 5.191

2.  Salivary defense factors and oral health in patients with common variable immunodeficiency.

Authors:  V Kirstilä; J Tenovuo; O Ruuskanen; J Nikoskelainen; K Irjala; P Vilja
Journal:  J Clin Immunol       Date:  1994-07       Impact factor: 8.317

Review 3.  The Na+/I- symporter (NIS): mechanism and medical impact.

Authors:  Carla Portulano; Monika Paroder-Belenitsky; Nancy Carrasco
Journal:  Endocr Rev       Date:  2013-12-04       Impact factor: 19.871

4.  Antibacterial activity of hydrogen peroxide and the lactoperoxidase-hydrogen peroxide-thiocyanate system against oral streptococci.

Authors:  E L Thomas; T W Milligan; R E Joyner; M M Jefferson
Journal:  Infect Immun       Date:  1994-02       Impact factor: 3.441

5.  Antimicrobial factors in whole saliva of human infants.

Authors:  J Tenovuo; O P Lehtonen; A S Aaltonen; P Vilja; P Tuohimaa
Journal:  Infect Immun       Date:  1986-01       Impact factor: 3.441

6.  Do folic acid and thiocyanate have a preventive effect on exogenously induced disturbances of embryonic cranial development?

Authors:  J Weingärtner; A Martens; V Bienengräber; J Fanghänel; G Kundt
Journal:  Clin Oral Investig       Date:  2004-06-23       Impact factor: 3.573

7.  Inhibition of dental plaque acid production by the salivary lactoperoxidase antimicrobial system.

Authors:  J Tenovuo; B Mansson-Rahemtulla; K M Pruitt; R Arnold
Journal:  Infect Immun       Date:  1981-10       Impact factor: 3.441

8.  Protection of cultured rat gastric cells against oxidant stress by iron chelation. Role of lipid peroxidation.

Authors:  N Yajima; H Hiraishi; T Harada
Journal:  Dig Dis Sci       Date:  1995-04       Impact factor: 3.199

9.  Protective role of intracellular superoxide dismutase against extracellular oxidants in cultured rat gastric cells.

Authors:  H Hiraishi; A Terano; T Sugimoto; T Harada; M Razandi; K J Ivey
Journal:  J Clin Invest       Date:  1994-01       Impact factor: 14.808

10.  Inhibition of Streptococcus mutans by the lactoperoxidase antimicrobial system.

Authors:  E L Thomas; K A Pera; K W Smith; A K Chwang
Journal:  Infect Immun       Date:  1983-02       Impact factor: 3.441
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