Extensive bone marrow infarction followed by myelofibrosis in patient with Ph' positive chronic granulocytic leukaemia.

A 28-year-old man with Philadelphia chromosome positive chronic granulocytic leukaemia developed extensive bone marrow and bone infarction which was associated with anaemia and thrombocytopenia. He survived 20 months from the first symptoms of bone marrow infarction; during this time he developed myelofibrosis and osteosclerosis followed by blastic transformation. Extensive bone marrow infarction is a possible pathogenetic mechanism when chronic granulocytic leukaemia is followed by myelofibrosis.