Literature DB >> 6929370

Destruction of human solid tumors by alkyl lysophospholipids.

M H Runge, R Andreesen, A Pfleiderer, P G Munder.   

Abstract

Alkyl lysophospholipids (ALP) are synthetic analogs of the naturally occurring 2-lysophosphatidylcholine. The effect of ALP on the proliferation of 22 different gynecologic malignant tumors in humans was studied in vitro. ALP caused progressive death of tumor cells over 24-96 hours. In addition, tumor specimens from the tested human tumors were xenotransplanted into NMRI nude mice. ALP induced a highly significant retardation of the in vivo growing human tumors. Neither oral nor iv administration of these compounds caused any recognizable side effects.

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Year:  1980        PMID： 6929370     DOI： 10.1093/jnci/64.6.1301

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  16 in total

1.  Activation of macrophages by ether analogues of lysophospholipids.

Authors:  N Yamamoto; B Z Ngwenya; T W Sery; R A Pieringer
Journal:  Cancer Immunol Immunother       Date:  1987       Impact factor: 6.968

2.  Antineoplastic activity of synthetic lysophospholipid analogs.

Authors:  W E Berdel
Journal:  Blut       Date:  1982-02

3.  Experimental studies on the role of alkyl lysophospholipids in autologous bone marrow transplantation.

Authors:  W R Vogler; A C Olson; S Okamoto; L B Somberg; L Glasser
Journal:  Lipids       Date:  1987-11       Impact factor: 1.880

4.  Antileukemic effect of alkyl phospholipids. II. Prolongation of survival times of leukemic mice by alkyl ethyleneglycophospholipids.

Authors:  Y Honma; T Kasukabe; J Okabe-Kado; M Hozumi; S Tsushima; H Nomura
Journal:  Cancer Chemother Pharmacol       Date:  1983       Impact factor: 3.333

5.  Clonogenicity of normal and malignant hematopoietic progenitor cells after exposure to synthetic alkyl-lymphospholipids.

Authors:  I Dulisch; H A Neumann; G W Löhr; R Andreesen
Journal:  Blut       Date:  1985-12

6.  Cytotoxicity of ether phospholipid BM 41.440 on neuroblastoma cells.

Authors:  R Girgert; P Schweizer; I Bock; R Narr; G Bruchelt
Journal:  J Cancer Res Clin Oncol       Date:  1995       Impact factor: 4.553

7.  Effects of inflammation products on immune systems. Lysophosphatidylcholine stimulates macrophages.

Authors:  B Z Ngwenya; N Yamamoto
Journal:  Cancer Immunol Immunother       Date:  1986       Impact factor: 6.968

8.  Edelfosine Promotes Apoptosis in Androgen-Deprived Prostate Tumors by Increasing ATF3 and Inhibiting Androgen Receptor Activity.

Authors:  Thirupandiyur S Udayakumar; Radka Stoyanova; Mohammed M Shareef; Zhaomei Mu; Sakhi Philip; Kerry L Burnstein; Alan Pollack
Journal:  Mol Cancer Ther       Date:  2016-03-04       Impact factor: 6.261

9.  Antineoplastic activity of the thioether lysophospholipid derivative BM 41.440 in vitro.

Authors:  M Fromm; W E Berdel; H D Schick; U Fink; W Pahlke; U Bicker; A Reichert; J Rastetter
Journal:  Lipids       Date:  1987-11       Impact factor: 1.880

10.  Structure-cytotoxicity studies on alkyl lysophospholipids and some analogs in leukemic blasts of human origin in vitro.

Authors:  S Danhauser; W E Berdel; H D Schick; M Fromm; A Reichert; U Fink; R Busch; H Eibl; J Rastetter
Journal:  Lipids       Date:  1987-11       Impact factor: 1.880
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