Literature DB >> 6928105

"Microgranular" acute promyelocytic leukemia: a distinct clinical, ultrastructural, and cytogenetic entity.

H M Golomb, J D Rowley, J W Vardiman, J R Testa, A Butler.   

Abstract

Three patients with acute leukemia, disseminated intravascular coagulation, and a specific acquired chromosome abnormality [t (15;17)] were found by transmission electron microscopy to have the typical distribution of granules seen in promyelocytes. However, the average granule sizes were 120, 170, and 180 nm, respectively, for the three patients, significantly less than the 250-nm resolution of light microscopy. We regard the leukemia in these three patients as comprising a distinct clinical, ultrastructural, and cytogenetic entity that we have chosen to call "microgranular" acute promyelocytic leukemia.

Entities:  

Mesh：

Year:  1980        PMID： 6928105

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  13 in total

1.  Atypical features in a patient with acute promyelocytic leukaemia: a potential diagnostic pitfall.

Authors:  Muhajir Mohamed; Karen Dun; Julian Grabek
Journal:  BMJ Case Rep       Date:  2013-09-06

Review 2.  Chromosome abnormalities in acute leukemia: its clinical implications and age of onset.

Authors:  R Abe; Y Shiga; T Uchida; S Kariyone
Journal:  Indian J Pediatr       Date:  1989 Nov-Dec       Impact factor: 1.967

Review 3.  Some aspects of immunological and cytochemical markers in leukemia.

Authors:  D Huhn
Journal:  Cancer Chemother Pharmacol       Date:  1980       Impact factor: 3.333

4.  Clinical characteristics, outcome and early induction deaths in patients with acute promyelocytic leukaemia: a five-year experience at a tertiary care centre.

Authors:  Farheen Karim; Usman Shaikh; Salman Naseem Adil; Mohammad Khurshid
Journal:  Singapore Med J       Date:  2014-08       Impact factor: 1.858

Review 5.  New advances in the treatment of acute promyelocytic leukemia.

Authors:  Dan Douer
Journal:  Int J Hematol       Date:  2002-08       Impact factor: 2.490

Review 6.  Acute promyelocytic leukaemia in the all trans retinoic acid era.

Authors:  T G DeLoughery; S H Goodnight
Journal:  Med Oncol       Date:  1996-12       Impact factor: 3.064

7.  Does microgranular variant morphology of acute promyelocytic leukemia independently predict a less favorable outcome compared with classical M3 APL? A joint study of the North American Intergroup and the PETHEMA Group.

Authors:  Martin S Tallman; Haesook T Kim; Pau Montesinos; Frederick R Appelbaum; Javier de la Serna; John M Bennett; Guillermo Deben; Clara D Bloomfield; Jose Gonzalez; James H Feusner; Marcos Gonzalez; Robert Gallagher; Jose D Gonzalez-San Miguel; Richard A Larson; Gustavo Milone; Elisabeth Paietta; Chelo Rayon; Jacob M Rowe; Concha Rivas; Charles A Schiffer; Edo Vellenga; Lois Shepherd; James L Slack; Peter H Wiernik; Cheryl L Willman; Miguel A Sanz
Journal:  Blood       Date:  2010-09-21       Impact factor: 22.113

8.  Multiple Jejunal Myeloid Sarcomas Presenting with Intestinal Obstruction in a Non-leukemic Patient: A Case Report with Ultrastructural Observations.

Authors:  Na Rae Kim; Woon Kee Lee; Jong In Lee; Hyun Yee Cho
Journal:  Korean J Pathol       Date:  2012-12-26

9.  Acute promyelocytic leukaemia with hypogranular bone marrow blasts in a 16-year-old girl: diagnostic value of different genetic methods.

Authors:  W Scherulen; J Harbott; J W Janssen; J Kühl; C R Bartram
Journal:  Eur J Pediatr       Date:  1995-05       Impact factor: 3.183

Review 10.  Diagnosis and treatment of acute promyelocytic leukemia.

Authors:  Joseph G Jurcic; Steven L Soignet; And Peter G Maslak
Journal:  Curr Oncol Rep       Date:  2007-09       Impact factor: 5.075
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