Literature DB >> 6927840

Nucleotide sequence of human preproinsulin complementary DNA.

I Sures, D V Goeddel, A Gray, A Ullrich.   

Abstract

Recombinant bacterial plasmids that contain DNA complementary to human preproinsulin messenger RNA have been constructed. One clone contains the entire preproinsulin coding region, as well as the 3' untranslated region of the messenger RNA and eight nucleotides of the 5' untranslated region. Additional sequence information for the 5' untranslated region was obtained with the use of insulinoma messenger RNA in conjunction with specific primers from the cloned DNA for enzymatic chain termination sequence analysis. The results confirm the amino acid sequence of human proinsulin previously determined, and predict the amino acid sequence of the human preproinsulin signal peptide.

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Year:  1980        PMID： 6927840     DOI： 10.1126/science.6927840

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Estimation of evolutionary distances between homologous nucleotide sequences.

Authors:  M Kimura
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205

2.  Codon catalog usage is a genome strategy modulated for gene expressivity.

Authors:  R Grantham; C Gautier; M Gouy; M Jacobzone; R Mercier
Journal:  Nucleic Acids Res       Date:  1981-01-10       Impact factor: 16.971

3.  [Protein semisynthesis with the help of mixed anhydrides and enzymes: chemistry and synthesis of insulins].

Authors:  H Zahn; V K Naithani; H G Gattner; E E Büllesbach; P M Thamm
Journal:  Naturwissenschaften       Date:  1981-02

4.  Pathogenetic mechanisms of hereditary diabetes mellitus.

Authors:  H W Rüdiger; M Dreyer
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

5.  Carp preproinsulin cDNA sequence and evolution of insulin genes.

Authors:  V Hahn; J Winkler; T A Rapoport; D H Liebscher; C Coutelle; S Rosenthal
Journal:  Nucleic Acids Res       Date:  1983-07-11       Impact factor: 16.971

6.  Demonstration of an endocrine signaling circuit for insulin in the sponge Geodia cydonium.

Authors:  A Robitzki; H C Schröder; D Ugarkovic; K Pfeifer; G Uhlenbruck; W E Müller
Journal:  EMBO J       Date:  1989-10       Impact factor: 11.598

7.  Making, Cloning, and the Expression of Human Insulin Genes in Bacteria: The Path to Humulin.

Authors:  Arthur D Riggs
Journal:  Endocr Rev       Date:  2021-05-25       Impact factor: 19.871

8.  Transplantation of the human insulin gene into fertilized mouse eggs.

Authors:  K Bürki; A Ullrich
Journal:  EMBO J       Date:  1982       Impact factor: 11.598

9.  A Tribute to Peter H Seeburg (1944-2016): A Founding Father of Molecular Neurobiology.

Authors:  William Wisden
Journal:  Front Mol Neurosci       Date:  2016-11-29       Impact factor: 5.639
  9 in total

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