Literature DB >> 6915076

The role of antibiotic tolerance in the response to treatment of pyelonephritis due to Staphylococcus aureus in rats.

P A Guze, G M Kalmanson, L B Guze.   

Abstract

The effect of tolerance to methicillin on the response to treatment of hematogenous pyelonephritis due to Staphylococcus aureus was evaluated in rats. Tolerance was defined as a ratio of minimal bactericidal concentration to minimal inhibitory concentration of greater than or equal to 32. Rats that were infected with tolerant or nontolerant stains of S. aureus were treated with methicillin with equal success as judged by the number of bacteria in the kidneys and the proportion of rats with infected kidneys. In this animal model, tolerance does not play a role in the outcome of treatment.

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Year:  1982        PMID： 6915076     DOI： 10.1093/infdis/145.2.169

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  8 in total

Review 1.  Antibiotic tolerance among clinical isolates of bacteria.

Authors:  E Tuomanen; D T Durack; A Tomasz
Journal:  Antimicrob Agents Chemother       Date:  1986-10       Impact factor: 5.191

Review 2.  Problems in in vitro determination of antibiotic tolerance in clinical isolates.

Authors:  J C Sherris
Journal:  Antimicrob Agents Chemother       Date:  1986-11       Impact factor: 5.191

3.  Variables in demonstrating methicillin tolerance in Staphylococcus aureus strains.

Authors:  K Ishida; P A Guze; G M Kalmanson; K Albrandt; L B Guze
Journal:  Antimicrob Agents Chemother       Date:  1982-04       Impact factor: 5.191

4.  Lack of reproducibility of macrodilution MBCs for Staphylococcus aureus.

Authors:  L L Pelletier
Journal:  Antimicrob Agents Chemother       Date:  1984-12       Impact factor: 5.191

5.  Responses of tolerant and nontolerant Staphylococcus aureus strains to methicillin treatment in an experimental infection in mice.

Authors:  W H Goessens; P Fontijne; M F Michel
Journal:  Antimicrob Agents Chemother       Date:  1984-12       Impact factor: 5.191

6.  Tolerance percentage as a criterion for the detection of tolerant Staphylococcus aureus strains.

Authors:  W H Goessens; P Fontijne; M van Raffe; M F Michel
Journal:  Antimicrob Agents Chemother       Date:  1984-05       Impact factor: 5.191

7.  Efficacy of penicillin G, flucloxacillin, cefazolin, fusidic acid, vancomycin, rifampicin and fosfomycin in muscular infections in mice due to Staphylococcus aureus.

Authors:  R Haag
Journal:  Infection       Date:  1986 Jan-Feb       Impact factor: 3.553

8.  Penicillin therapy of experimental endocarditis induced by tolerant Streptococcus sanguis and nontolerant Streptococcus mitis.

Authors:  F D Lowy; E G Neuhaus; D S Chang; N H Steigbigel
Journal:  Antimicrob Agents Chemother       Date:  1983-01       Impact factor: 5.191
  8 in total

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