Literature DB >> 691197

Toxicity of penicillamine. A serious limitation to therapy in rheumatoid arthritis.

P B Halverson, F Kozin, G C Bernhard, A L Goldman.   

Abstract

A retrospective study of penicillamine toxicity in 156 patients yielded a high incidence of toxic reaction (62%), necessitating discontinuation of the drug therapy in 36% of the patients. Of the total group, proteinuria occurred in 14%, hematologic toxic reaction in 11%, mucocutaneous toxic reaction in 28%, and gastrointestinal intolerance in 12%.

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Year:  1978        PMID： 691197     DOI： 10.1001/jama.240.17.1870

Source DB:  PubMed          Journal:  JAMA        ISSN： 0098-7484            Impact factor:   56.272


  6 in total

1.  Thrombokinetics in patients with rheumatoid arthritis treated with D-penicillamine.

Authors:  D Thomas; A S Gallus; P M Brooks; R Tampi; R Geddes; W Hill
Journal:  Ann Rheum Dis       Date:  1984-06       Impact factor: 19.103

Review 2.  Drug-induced nephrotoxicity. Aetiology, clinical features and management.

Authors:  A J Hoitsma; J F Wetzels; R A Koene
Journal:  Drug Saf       Date:  1991 Mar-Apr       Impact factor: 5.606

3.  D-penicillamine in pregnancy--to ban or not to ban?

Authors:  W Endres
Journal:  Klin Wochenschr       Date:  1981-06-01

4.  Wilson's disease: assessment of D-penicillamine treatment.

Authors:  M Van Caillie-Bertrand; H J Degenhart; I Luijendijk; J Bouquet; M Sinaasappel
Journal:  Arch Dis Child       Date:  1985-07       Impact factor: 3.791

5.  The metabolism and disposition of D-penicillamine in the DA-strain rat.

Authors:  A E Pilkington; R H Waring
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1988 Apr-Jun       Impact factor: 2.441

6.  [D-Penacillamine. From constituent of penicillins to significant drug].

Authors:  E Lodemann
Journal:  Naturwissenschaften       Date:  1979-09
  6 in total

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