[Pigmented deposits into conjunctiva after local application of epinephrine (author's transl)].

Prolonged local application of epinephrine produces deposits of pigment in the conjunctiva, which is found in conjunctival cysts or crypts. The fine granular structure sometimes shows concentric layers. Granular particles seen by electron microscope are often found adsorbed to the surface of microvilli. It is not known whether the electron-sense particles in the cysts or crypts have developed from active secretion or by influx from the conjunctival surface. The metabolic product of locally applied epinephrine is probably not a typical melanin (negative Masson-Hamperl staining), but appears to be a related pigment.