Literature DB >> 690853

New compounds: antitumor activity of 3beta-hydroxy-13alpha-amino-13,17-seco-5alpha-androstan-17-oic-13,17-lactam 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrate.

P Catsoulacos, D Politis, L Boutis, A Papageorgiou.   

Abstract

3beta-Hydroxy-13alpha-amino-13,17-seco-5alpha-androstan-17-oic-13,17-lactam 4-[p[bis(2chloroethyl)amino]phenyl]butyrate was prepared by reacting 4-[p-[bis(2-chloroethyl)amino]phenyl]butyryl chloride hydrochloride with 3beta-hydroxy-13alpha-amino-13,17-seco-5alpha-androstan-17-oic-13,17-lactam. They cytostatic action of the ester was investigated on two tumor systems (B16 melanoma on C57 b1 mice and T8-Guerin on rats).

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 690853     DOI： 10.1002/jps.2600670948

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  2 in total

1.  A new steroidal alkylating agent with improved activity in advanced murine leukemias.

Authors:  P Catsoulacos; D Politis; G L Wampler
Journal:  Cancer Chemother Pharmacol       Date:  1979       Impact factor: 3.333

2.  Antitumor activity of homo-aza-steroidal esters of [p-[bis(2-chloroethyl)amino]phenyl]acetic acid and [p-[bis(2-chloroethyl)amino]phenyl]butyric acid.

Authors:  P Catsoulacos; D Politis; G L Wampler
Journal:  Cancer Chemother Pharmacol       Date:  1983       Impact factor: 3.333
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.