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Literature DB >> 6906142

Effects of timolol maleate on tear flow in human eyes.

L Bonomi, G Zavarise, E Noya, S Michieletto.

Abstract

Lacrimal function was studied in 30 patients treated for glaucoma, with 0.25% timolol eye drops. Rose bengal and fluorescein staining disclosed punctate epithelial defects in 11 eyes after one week. During the following weeks there defects disappeared spontaneously in most eyes. Schirmer tests (I and II), tear lysozyme and pre-corneal film break-up time were significantly decreased by the treatment, while tear immunoglobulins were unimpaired. The authors conclude that topical timolol treatment decreases tear production. This effect is quantitatively limited and does not appear dangerous for normal eyes, although it may become so for eyes with an originally low lacrimal secretion.

Entities: Chemical Disease Species

Mesh：

Substances：
Propanolamines
Timolol

Year: 1980 PMID： 6906142 DOI： 10.1007/bf02391207

Source DB: PubMed Journal: Albrecht Von Graefes Arch Klin Exp Ophthalmol ISSN： 0065-6100

13 in total

1. Untoward effects associated with practolol administration: oculomucocutaneous syndrome.

Authors: P Wright
Journal: Br Med J Date: 1975-03-15

2. A spectrophotometric method for quantitative determination of lysozyme in human tears: description and evaluation of the method and screening of 60 healthy subjects.

Authors: D Ronen; E Eylan; A Romano; R Stein; M Modan
Journal: Invest Ophthalmol Date: 1975-06

Effects of timolol maleate on tear flow in human eyes.

1. Untoward effects associated with practolol administration: oculomucocutaneous syndrome.

2. A spectrophotometric method for quantitative determination of lysozyme in human tears: description and evaluation of the method and screening of 60 healthy subjects.

3. Vital staining of cornea and conjunctiva. Fluorescein-rose bengal mixture and tetrazolium-alcian blue mixture.

4. [Methods for the quantitative determination of plasma proteins by immunoprecipitation].

5. Diurnal profiles of tear lysozyme and gamma A globulin.

6. Beta-adrenergic receptor blocking drugs: tear lysozyme and immunological screening for adverse reaction.

7. Pathology of practolol-induced ocular toxicity.

8. Long-term experience with timolol ophthalmic solution in patients with open-angle glaucoma.

9. [Experimental studies with timolol: a new ocular hypotensive agent (author's transl)].

10. Timolol transitory manifestations of dry eyes in long term treatment.

1. Effects of short-term oral administration of propranolol on tear secretion in clinically normal dogs.

2. Influence of topical and systemic beta-blockers on tear production.

Review 3. Pharmacological therapy for glaucoma: a review.

4. Ultrastructural changes of the rabbit corneal epithelium and endothelium after Timoptic treatment.

Review 5. Adverse effects of topical antiglaucomatous medications on the conjunctiva.

Review 6. Tear analysis in contact lens wearers.

7. Effects of long-term treatment with timolol on lacrimal gland function.

Review 8. Ocular beta-blockers in glaucoma management. Clinical pharmacological aspects.

9. Pharmacogenetics of ophthalmic topical beta-blockers.

10. The influence of long-term treatment with timolol on human tear lysozyme albumin content.