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Literature DB >> 6905765

Stimulation of human cardiac adenylate cyclase by vanadate.

Abstract

Experiments have been carried out to characterize the influence of the positive inotropic trace element vanadium (used as Na3VO4) on beta-adrenergic receptor coupled adenylate cyclase activity from human myocardium. Na3VO4 (10(4)M) stimulates basal activity as well as isoprenaline (10 microM)- and Mg2+ (20 mM) activated enzyme activity 1.5-2.4-fold. In contrast, adenylate cyclase activity in the presence of maximally activating concentrations of Gpp(NH)p (10 microM) cannot be further increased by Na3VO4. The results confirm the assumption (5) that vanadate stimulates adenylate cyclase by interacting with the nucleotide-binding site of this enzyme.

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Year: 1980 PMID： 6905765 DOI： 10.1007/bf01908407

Source DB: PubMed Journal: Basic Res Cardiol ISSN： 0300-8428 Impact factor: 17.165

12 in total

Review 1. Membrane adenosinetriphosphatase: a digitalis receptor?

Authors: T Akera
Journal: Science Date: 1977-11-11 Impact factor: 47.728

2. Stimulatory effect of vanadate on the adenylate cyclase of cardiac tissue.

Authors: W Krawietz; K Werdan; E Erdmann
Journal: Biochem Pharmacol Date: 1979-08-15 Impact factor: 5.858

Review 3. Role of adenine and guanine nucleotides in the activity and response of adenylate cyclase systems to hormones: evidence for multisite transition states.

Authors: M Rodbell; M C Lin; Y Salomon; C Londos; J P Harwood; B R Martin; M Rendell; M Berman
Journal: Adv Cyclic Nucleotide Res Date: 1975

4. A highly sensitive adenylate cyclase assay.

Authors: Y Salomon; C Londos; M Rodbell
Journal: Anal Biochem Date: 1974-04 Impact factor: 3.365

5. The effect of epinephrine on adenosine 3', 5'-phosphate levels in the isolated perfused rat heart.

Authors: G A Robison; R W Butcher; I Oye; H E Morgan; E W Sutherland
Journal: Mol Pharmacol Date: 1965-09 Impact factor: 4.436

6. Effects of vanadate ions on action potentials and tension development in papillary muscles and cultured heart muscle cells.

Authors: H A Tritthart; B Koidl; H Windisch
Journal: Basic Res Cardiol Date: 1980 May-Jun Impact factor: 17.165

7. Positive inotropism of vanadate in cat papillary muscle.

Authors: I Hackbarth; W Schmitz; H Scholz; E Erdmann; W Krawietz; G Philipp
Journal: Nature Date: 1978-09-07 Impact factor: 49.962

8. Effects of vanadate in cultured rat heart muscle cells. Vanadate transport, intracellular binding and vanadate-induced changes in beating and in active cation flux.

Authors: K Werdan; G Bauriedel; M Bozsik; W Krawietz; E Erdmann
Journal: Biochim Biophys Acta Date: 1980-04-10

9. Mechanism of adenylate cyclase activation by cholera toxin: inhibition of GTP hydrolysis at the regulatory site.

Authors: D Cassel; Z Selinger
Journal: Proc Natl Acad Sci U S A Date: 1977-08 Impact factor: 11.205

10. Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle.

Authors: L C Cantley; L Josephson; R Warner; M Yanagisawa; C Lechene; G Guidotti
Journal: J Biol Chem Date: 1977-11-10 Impact factor: 5.157

2 in total

1. Negative inotropic effect of vanadate in ventricular myocardium in the presence of 3-isobutyl-1-methylxanthine or isoprenaline.

Authors: R Brückner; W Schmitz; H Scholz; A Schumacher; E Erdmann; W Krawietz; K Werdan
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1980 Impact factor: 3.000

2. Vanadate-Induced Renal cAMP and Malondialdehyde Accumulation Suppresses Alpha 1 Sodium Potassium Adenosine Triphosphatase Protein Levels.

Authors: Somchit Eiam-Ong; Yuyen Nakchui; Mookda Chaipipat; Somchai Eiam-Ong
Journal: Toxicol Res Date: 2018-04-15

2 in total