Literature DB >> 6903261

Increased kallikrein excretion in spontaneously hypertensive rats and its inhibition by 6-hydroxydopamine.

W Rascher, G Bönner, M Stocker, F Gross.   

Abstract

Urinary kallikrein excretion was studied in young, stroke-prone, spontaneously hypertensive rats (spSHR). Seven-week-old spSHR were found to excrete more kallikrein into the urine than normotensive Wistar Kyoto control rats (WKR). "Chemical sympathectomy", induced by 6-hydroxydopamine (6-OHDA) immediately after birth, resulted in normotensive blood-pressure levels and in a reduction of kallikrein in spSHR. In normotensive WKR, blood pressure and urinary kallikrein excretion were only slightly diminished by 6-OHDA. The results suggest a relationship between sympathetic activity and kallikrein excretion, being especially pronounced in spSHR, which have an elevated sympathetic activity.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6903261     DOI： 10.1007/bf00498573

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  11 in total

1.  The nature of the kallidins released from human plasma by kallikreins and other enzymes.

Authors:  M E WEBSTER; J V PIERCE
Journal:  Ann N Y Acad Sci       Date:  1963-02-04       Impact factor: 5.691

2.  Urinary kallikrein excretion in spontaneously hypertensive rats.

Authors:  R G Geller; H S Margolius; J J Pisano; H R Keiser
Journal:  Circ Res       Date:  1975-06       Impact factor: 17.367

3.  Sympathetic vascular tone in spontaneous hypertension of rats.

Authors:  A Schömig; R Dietz; W Rascher; J B Lüth; J F Mann; M Schmidt; J Weber
Journal:  Klin Wochenschr       Date:  1978

4.  Altered urinary kallikrein excretion in human hypertension.

Authors:  H S Margolis; R Geller; J J Pisano; A Sjoerdsma
Journal:  Lancet       Date:  1971-11-13       Impact factor: 79.321

5.  Evaluation of sodium and potassium balance in rats.

Authors:  J Möhring; B Möhring
Journal:  J Appl Physiol       Date:  1972-11       Impact factor: 3.531

6.  Altered urinary kallikrein excretion in rats with hypertension.

Authors:  H S Margolius; R Geller; W De Jong; J J Pisano; A Sjoerdsma
Journal:  Circ Res       Date:  1972-03       Impact factor: 17.367

7.  The distribution and secretion of kallikrein in some exocrine organs of the rat.

Authors:  T B Orstavik
Journal:  Acta Physiol Scand       Date:  1978-12

8.  Urinary kallikrein in hypertensive animal models.

Authors:  H R Keiser; R G Geller; H S Margolius; J J Pisano
Journal:  Fed Proc       Date:  1976-02

9.  Application of bradykinin radioimmunoassay for the measurement of urinary kallikrein activity rats.

Authors:  M Stocker; J Hornung
Journal:  Klin Wochenschr       Date:  1978

Review 10.  The renal kallikrein-kinin system in human and in experimental hypertension.

Authors:  O A Carretero; A G Scicli
Journal:  Klin Wochenschr       Date:  1978
View more
  2 in total

1.  The renal kallikrein-kinin system in spontaneously hypertensive rats.

Authors:  G Bönner; T Unger; W Rascher; G Speck; D Ganten; F Gross
Journal:  Agents Actions       Date:  1984-10

2.  Relationships between kallikrein secretion, kallikrein excretion and beta-adrenoceptors in kidney cortical slices from neurogenic hypertensive dogs.

Authors:  C Damase-Michel; G Bompart; G Durrieu; J L Montastruc; P Montastruc; J P Girolami
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.