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Literature DB >> 6901664

Ureteral contractions induced by rat urine in vitro: probable involvement of renal kallikrein.

Abstract

Rat urine, even at a 1:10 final dilution in Tyrode's solution, stimulates contraction of the ureteral musculature in vitro. This effect can be ascribed to the presence of kallikrein or a kallikrein-like enzyme in urine. Isometric contractions of ureters were prevented by previous addition of aprotinin to the organ bath. Urine also lost its activity after inactivation of enzymes by heat or acid treatment.

Entities: Gene Species

Mesh：

Substances：
Kallikreins

Year: 1980 PMID： 6901664 DOI： 10.1007/bf01978618

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

13 in total

1. Human urinary and plasma kinins: relationship to sodium-retaining steroids and plasma renin activity.

Authors: J M Vinci; R M Zusman; J L Izzo; R E Bowden; D Horwitz; J J Pisano; H R Keiser
Journal: Circ Res Date: 1979-02 Impact factor: 17.367

2. Cellular origin of urinary kallikreins.

Authors: T B Orstabik; K Nustad; P Brandtzaeg; J V Pierce
Journal: J Histochem Cytochem Date: 1976-09 Impact factor: 2.479

3. Bumetanide induced increase of renal blood flow in conscious dogs and its relation to local renal hormones (PGE, kallikrein and renin).

Authors: U B Olsen; I Ahnfelt-Ronne
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1976-03

Ureteral contractions induced by rat urine in vitro: probable involvement of renal kallikrein.

1. Human urinary and plasma kinins: relationship to sodium-retaining steroids and plasma renin activity.

2. Cellular origin of urinary kallikreins.

3. Bumetanide induced increase of renal blood flow in conscious dogs and its relation to local renal hormones (PGE, kallikrein and renin).

4. Relation between urinary kallikrein and renal function, hypertension, and excretion of sodium and water in man.

5. Kallikrein-like activity in the urine of renal hypertensive rats.

6. Isolation of membrane-bound renal kallikrein and kininase.

7. Site of kininogenase secretion in the dog nephron.

8. Oxytocic esterase in rat urine.

9. Bradykinin: effect on ureteral peristalsis.

10. Kallikreinlike activity in perfusates and urine of isolated rat kidneys.

1. Inhibition of the ureteral contractions induced by rat urine with kallikrein antibodies.