Literature DB >> 690004

Biological activity of SCH 21420, the 1-N-S-alpha-hydroxy-beta-aminopropionyl derivative of gentamicin B.

G H Miller, P J Chiu, J A Waitz.   

Abstract

Sch 21420, the 1-N-HAPA derivative of gentamicin B, has been compared to gentamicin, tobramycin and amikacin in a variety of in vitro and in vivo tests. Based on studies with a large number of sensitive and resistant bacteria, it was shown that Sch 21420 has a spectrum and potency essentially the same as that of amikacin. Serum levels in mice, rats, and dogs are similar to those of other aminoglycosides. Sch 21420 was found to be markedly less toxic than amikacin in chronic renal function tests in rats and thus appears to have an advantageously improved therapeutic index compared to amikacin.

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Year:  1978        PMID： 690004     DOI： 10.7164/antibiotics.31.688

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  8 in total

Review 1.  Aminoglycoside research 1975-1985: prospects for development of improved agents.

Authors:  K E Price
Journal:  Antimicrob Agents Chemother       Date:  1986-04       Impact factor: 5.191

2.  Interpretive standards for disk susceptibility tests with Sch 21420 and amikacin.

Authors:  A L Barry; C Thornsberry; R N Jones; E H Gerlach
Journal:  Antimicrob Agents Chemother       Date:  1980-10       Impact factor: 5.191

3.  Resistance to amikacin and isepamicin in rabbits with experimental endocarditis of an aac(6')-Ib-bearing strain of Klebsiella pneumoniae susceptible in vitro.

Authors:  E Caulin; A Coutrot; C Carbon; E Collatz
Journal:  Antimicrob Agents Chemother       Date:  1996-12       Impact factor: 5.191

4.  Comparison of in vitro activity of Sch 21420, a gentamicin B derivative, with those of amikacin, gentamicin, netilmicin, sisomicin, and tobramycin.

Authors:  C Thornsberry; A L Barry; R N Jones; C N Baker; R E Badal; R R Packer
Journal:  Antimicrob Agents Chemother       Date:  1980-08       Impact factor: 5.191

5.  Nonparallel nephrotoxicity dose-response curves of aminoglycosides.

Authors:  G H Hottendorf; D Barnett; L L Gordon; E F Christensen; H Madissoo
Journal:  Antimicrob Agents Chemother       Date:  1981-06       Impact factor: 5.191

6.  Comparison of aminoglycoside resistance patterns in Japan, Formosa, and Korea, Chile, and the United States.

Authors:  K Shimizu; T Kumada; W C Hsieh; H Y Chung; Y Chong; R S Hare; G H Miller; F J Sabatelli; J Howard
Journal:  Antimicrob Agents Chemother       Date:  1985-08       Impact factor: 5.191

Review 7.  Aminoglycosides: nephrotoxicity.

Authors:  M P Mingeot-Leclercq; P M Tulkens
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

Review 8.  Amphiphilic aminoglycosides: Modifications that revive old natural product antibiotics.

Authors:  Jon Y Takemoto; Guillermo A Altenberg; Naveena Poudyal; Yagya P Subedi; Cheng-Wei T Chang
Journal:  Front Microbiol       Date:  2022-09-23       Impact factor: 6.064
  8 in total

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