Literature DB >> 690003

The syntheses and biological properties of 1-N-(S-4-amino-2-hydroxybutyryl)-gentamicin B and 1-N-(S-3-amino-2-hydroxypropionyl)-gentamicin B.

T L Nagabhushan, A B Cooper, H Tsai, P J Daniels, G H Miller.   

Abstract

The syntheses of 1-N-(S-4-amino-2-hydroxybutyryl)-gentamicin B and 1-N-(S-3-amino-2-hydroxypropionyl)-gentamicin B, designated sch 20287 and Sch 21420, respectively, by procedures similar to those developed by KAWAGUCHI and co-workers for the transformation of kanamycin A to amikacin are described. The in vitro microbiological properties of Sch 20287 and Sch 21420 are compared with amikacin, gentamicin and tobramycin.

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Year:  1978        PMID： 690003     DOI： 10.7164/antibiotics.31.681

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  15 in total

Review 1.  Aminoglycosides: activity and resistance.

Authors:  M P Mingeot-Leclercq; Y Glupczynski; P M Tulkens
Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

Review 2.  Aminoglycoside research 1975-1985: prospects for development of improved agents.

Authors:  K E Price
Journal:  Antimicrob Agents Chemother       Date:  1986-04       Impact factor: 5.191

3.  Interpretive standards for disk susceptibility tests with Sch 21420 and amikacin.

Authors:  A L Barry; C Thornsberry; R N Jones; E H Gerlach
Journal:  Antimicrob Agents Chemother       Date:  1980-10       Impact factor: 5.191

Review 4.  Destination of aminoglycoside antibiotics in the 'post-antibiotic era'.

Authors:  Yoshiaki Takahashi; Masayuki Igarashi
Journal:  J Antibiot (Tokyo)       Date:  2017-10-25       Impact factor: 2.649

5.  Collisionally activated dissociations of aminocyclitol-aminoglycoside antibiotics and their application in the identification of a new compound in tobramycin samples.

Authors:  P Hu; E K Chess; S Brynjelsen; G Jakubowski; J Melchert; R B Hammond; T D Wilson
Journal:  J Am Soc Mass Spectrom       Date:  2000-03       Impact factor: 3.109

6.  Synthesis and antibacterial activity of 1-N-[(S)-ω-amino-2-hydroxyalkyl] derivatives of dibekacin, 5-deoxydibekacin, 3'-deoxykanamycin A and gentamicin B.

Authors:  Eijiro Umemura; Yukou Sakamoto; Yoshiaki Takahashi; Toshiaki Miyake
Journal:  J Antibiot (Tokyo)       Date:  2015-02-25       Impact factor: 2.649

7.  Comparison of in vitro activity of Sch 21420, a gentamicin B derivative, with those of amikacin, gentamicin, netilmicin, sisomicin, and tobramycin.

Authors:  C Thornsberry; A L Barry; R N Jones; C N Baker; R E Badal; R R Packer
Journal:  Antimicrob Agents Chemother       Date:  1980-08       Impact factor: 5.191

8.  Isepamicin disposition in subjects with various degrees of renal function.

Authors:  C E Halstenson; J S Kelloway; M B Affrime; C C Lin; M A Teal; B E Shapiro; W M Awni
Journal:  Antimicrob Agents Chemother       Date:  1991-11       Impact factor: 5.191

9.  Structural basis of APH(3')-IIIa-mediated resistance to N1-substituted aminoglycoside antibiotics.

Authors:  Desiree H Fong; Albert M Berghuis
Journal:  Antimicrob Agents Chemother       Date:  2009-05-11       Impact factor: 5.191

Review 10.  Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance.

Authors:  Kun Shi; Shane J Caldwell; Desiree H Fong; Albert M Berghuis
Journal:  Front Cell Infect Microbiol       Date:  2013-06-25       Impact factor: 5.293
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