Literature DB >> 6898623

A phosphorylated keratohyalin-derived precursor of epidermal stratum corneum basic protein.

J D Lonsdale-Eccles, J A Haugen, B A Dale.   

Abstract

The precursor of the cationic protein called stratum corneum basic protein (SCBP) has been purified from extracts of epidermal keratohyalin granules. The precursor and SCBP have virtually identical amino acid compositions and similar reactivities to antibody to SCBP. Peptide mapping studies using elastase in sodium dodecyl sulfate (SDS)-polyacrylamide gels suggest that the primary amino acid sequences of SCBP and the precursor are similar. The proteins differ in their mobilities on SDS-polyacrylamide gel electrophoresis and in their net charges. The lower pI of the precursor (6.9) appears to be due to 15 to 20 mol of covalently bound phosphate per mol of protein; SCBP contains no phosphate.

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Year:  1980        PMID： 6898623

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  16 in total

1.  The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis.

Authors:  M Simon; E Girbal; M Sebbag; V Gomès-Daudrix; C Vincent; G Salama; G Serre
Journal:  J Clin Invest       Date:  1993-09       Impact factor: 14.808

2.  Normal human epidermal keratinocytes express in vitro specific molecular forms of (pro)filaggrin recognized by rheumatoid arthritis-associated antifilaggrin autoantibodies.

Authors:  E Girbal-Neuhauser; M Montézin; F Croute; M Sebbag; M Simon; J J Durieux; G Serre
Journal:  Mol Med       Date:  1997-02       Impact factor: 6.354

3.  Characterization of a class of cationic proteins that specifically interact with intermediate filaments.

Authors:  P M Steinert; J S Cantieri; D C Teller; J D Lonsdale-Eccles; B A Dale
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

Review 4.  Revisiting the Roles of Filaggrin in Atopic Dermatitis.

Authors:  Verena Moosbrugger-Martinz; Corinne Leprince; Marie-Claire Méchin; Michel Simon; Stefan Blunder; Robert Gruber; Sandrine Dubrac
Journal:  Int J Mol Sci       Date:  2022-05-10       Impact factor: 6.208

5.  Immunohistochemical detection of filaggrin in preneoplastic and neoplastic lesions of the human oral mucosa.

Authors:  M E Itoiz; C J Conti; H E Lanfranchi; M Mamrack; A J Klein-Szanto
Journal:  Am J Pathol       Date:  1985-06       Impact factor: 4.307

6.  Cyanogen bromide cleavage of proteins in sodium dodecyl sulphate/polyacrylamide gels. Diagonal peptide mapping of proteins from epidermis.

Authors:  J D Lonsdale-Eccles; A M Lynley; B A Dale
Journal:  Biochem J       Date:  1981-09-01       Impact factor: 3.857

7.  Profilaggrin is a major epidermal calcium-binding protein.

Authors:  N G Markova; L N Marekov; C C Chipev; S Q Gan; W W Idler; P M Steinert
Journal:  Mol Cell Biol       Date:  1993-01       Impact factor: 4.272

8.  Regulation of the expression of epidermal keratinocyte proliferation and differentiation by vitamin A analogs.

Authors:  C L Marcelo; K C Madison
Journal:  Arch Dermatol Res       Date:  1984       Impact factor: 3.017

9.  Dual regulation of intermediate filament phosphorylation.

Authors:  M E Gilmartin; J Mitchell; A Vidrich; I M Freedberg
Journal:  J Cell Biol       Date:  1984-03       Impact factor: 10.539

10.  Identification of two intermediates during processing of profilaggrin to filaggrin in neonatal mouse epidermis.

Authors:  K A Resing; K A Walsh; B A Dale
Journal:  J Cell Biol       Date:  1984-10       Impact factor: 10.539
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