| Literature DB >> 6897651 |
R Boulieu, C Bory, P Baltassat, C Gonnet.
Abstract
A rapid and selective reversed-phase high-performance liquid chromatographic method for the simultaneous determination of hypoxanthine and xanthine in biological fluids was developed. The identification of hypoxanthine and xanthine was confirmed by xanthine oxidase reaction. This method was applied to the investigation of purine metabolism in subjects with xanthine oxidase deficiency or gout. Hypoxanthine concentrations three to ten times higher than those determined in plasma were found in erythrocyte samples from normal subjects and from patients with xanthine oxidase deficiency or hyperuricemia under allopurinol therapy.Entities:
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Year: 1982 PMID： 6897651 DOI： 10.1016/s0378-4347(00)81739-9
Source DB: PubMed Journal: J Chromatogr