Literature DB >> 6897419

Suppression of hyperbilirubinemia in the rat neonate by chromium-protoporphyrin. Interactions of metalloporphyrins with microsomal heme oxygenase of human spleen.

G S Drummond, A Kappas.   

Abstract

The synthetic metalloporphyrin, Cr-protoporphyrin, as a potent competitive inhibitor of heme oxygenase activity in rat spleen, liver, and kidney. When administered to neonatal animals in a single dose immediately after birth, Cr-protoporphyrin suppresses postnatal hyperbilirubinemia and produces a marked and sustained lowering of heme oxidation activity in liver, spleen, and kidney. The metalloporphyrin also potently inhibited the rate of heme degradation to bile pigment in human spleen.

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Year:  1982        PMID： 6897419      PMCID： PMC2186871          DOI： 10.1084/jem.156.6.1878

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  13 in total

1.  Microsomal heme oxygenase. Characterization of the enzyme.

Authors:  R Tenhunen; H S Marver; R Schmid
Journal:  J Biol Chem       Date:  1969-12-10       Impact factor: 5.157

2.  The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.

Authors:  R Tenhunen; H S Marver; R Schmid
Journal:  Proc Natl Acad Sci U S A       Date:  1968-10       Impact factor: 11.205

3.  [Fluorimetric assay of bilirubin].

Authors:  M Roth
Journal:  Clin Chim Acta       Date:  1967-09       Impact factor: 3.786

4.  Manganese and zinc blockade of enzyme induction: studies with microsomal heme oxygenase.

Authors:  G S Drummond; A Kappas
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

5.  Enzymatic oxidation of cobalt protoporphyrin IX: observations on the mechanism of heme oxygenase action.

Authors:  M D Maines; A Kappas
Journal:  Biochemistry       Date:  1977-02-08       Impact factor: 3.162

6.  Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation.

Authors:  G S Drummond; A Kappas
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205

7.  Zinc . protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat.

Authors:  M D Maines
Journal:  Biochim Biophys Acta       Date:  1981-03-18

8.  Metal ion-mediated regulation of heme oxygenase induction in cultured avian liver cells.

Authors:  M K Sardana; S Sassa; A Kappas
Journal:  J Biol Chem       Date:  1982-05-10       Impact factor: 5.157

9.  Metal ion interactions in the control of haem oxygenase induction in liver and kidney.

Authors:  G S Drummond; A Kappas
Journal:  Biochem J       Date:  1980-11-15       Impact factor: 3.857

10.  Study of the developmental pattern of heme catabolism in liver and the effects of cobalt on cytochrome P-450 and the rate of heme oxidation during the neonatal period.

Authors:  M D Maines; A Kappas
Journal:  J Exp Med       Date:  1975-06-01       Impact factor: 14.307
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  11 in total

1.  Sn-protoporphyrin inhibition of fetal and neonatal brain heme oxygenase. Transplacental passage of the metalloporphyrin and prenatal suppression of hyperbilirubinemia in the newborn animal.

Authors:  G S Drummond; A Kappas
Journal:  J Clin Invest       Date:  1986-03       Impact factor: 14.808

2.  The liver excretes large amounts of heme into bile when heme oxygenase is inhibited competitively by Sn-protoporphyrin.

Authors:  A Kappas; C S Simionatto; G S Drummond; S Sassa; K E Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

3.  Sn-protoporphyrin rapidly and markedly enhances the heme saturation of hepatic tryptophan pyrrolase. Evidence that this synthetic metalloporphyrin increases the functional content of heme in the liver.

Authors:  A Kappas; G S Drummond; M K Sardana
Journal:  J Clin Invest       Date:  1985-01       Impact factor: 14.808

4.  Studies with the haeme oxygenase inhibitor Sn-protoporphyrin in patients with primary biliary cirrhosis and idiopathic haemochromatosis.

Authors:  L Berglund; B Angelin; R Hultcrantz; K Einarsson; L Emtestam; G Drummond; A Kappas
Journal:  Gut       Date:  1990-08       Impact factor: 23.059

5.  Heme Inhibition of [delta]-Aminolevulinic Acid Synthesis Is Enhanced by Glutathione in Cell-Free Extracts of Chlorella.

Authors:  J. D. Weinstein; R. W. Howell; R. D. Leverette; S. Y. Grooms; P. S. Brignola; S. M. Mayer; S. I. Beale
Journal:  Plant Physiol       Date:  1993-02       Impact factor: 8.340

6.  Dual control mechanism for heme oxygenase: tin(IV)-protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver.

Authors:  M K Sardana; A Kappas
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

7.  Studies on the mechanism of Sn-protoporphyrin suppression of hyperbilirubinemia. Inhibition of heme oxidation and bilirubin production.

Authors:  C S Simionatto; K E Anderson; G S Drummond; A Kappas
Journal:  J Clin Invest       Date:  1985-02       Impact factor: 14.808

8.  An experimental model of postnatal jaundice in the suckling rat. Suppression of induced hyperbilirubinemia by Sn-protoporphyrin.

Authors:  G S Drummond; A Kappas
Journal:  J Clin Invest       Date:  1984-07       Impact factor: 14.808

9.  Metalloporphyrins-Applications and clinical significance.

Authors:  R Chandra; M Tiwari; P Kaur; M Sharma; R Jain; S Dass
Journal:  Indian J Clin Biochem       Date:  2000-08

10.  Metalloporphyrins - an update.

Authors:  Stephanie Schulz; Ronald J Wong; Hendrik J Vreman; David K Stevenson
Journal:  Front Pharmacol       Date:  2012-04-26       Impact factor: 5.810
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