Literature DB >> 6896115

Leukotrienes C and D induce aspirin-sensitive bronchoconstriction in the guinea-pig.

B B Vargaftig, J Lefort, R C Murphy.   

Abstract

Branchoconstriction in the guinea-pig due to leukotrienes C4 and D4 in vivo and in vitro was suppressed by aspirin. Since contracting effects of putative mediators of bronchial asthma should be refractory to inhibition of cyclooxygenase, our results indicate that release of leukotrienes in the guinea-pig does not alone account for anaphylactic bronchoconstriction.

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Year:  1981        PMID: 6896115     DOI: 10.1007/bf01978747

Source DB:  PubMed          Journal:  Agents Actions        ISSN: 0065-4299


  12 in total

1.  Interaction between the release of SRS-A and of prostaglandins [proceedings].

Authors:  D M Engineer; P J Piper; P Sirois
Journal:  Br J Pharmacol       Date:  1976-07       Impact factor: 8.739

2.  Release of vasoactive substances from guinea-pig lungs by slow-reacting substance c and arachidonic acid. Its blockade by nonsteroid anti-inflammatory agents.

Authors:  B B Vargaftig; N Dao
Journal:  Pharmacology       Date:  1971       Impact factor: 2.547

3.  Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs.

Authors:  P J Piper; J R Vane
Journal:  Nature       Date:  1969-07-05       Impact factor: 49.962

4.  Inhibition of adenosine diphosphate-induced secondary aggregation and other platelet functions by acetylsalicylic acid ingestion.

Authors:  M B Zucker; J Peterson
Journal:  Proc Soc Exp Biol Med       Date:  1968-02

5.  Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives.

Authors:  B B Vargaftig; J Lefort; M Chignard; J Benveniste
Journal:  Eur J Pharmacol       Date:  1980-07-25       Impact factor: 4.432

6.  The cat lung strip as an in vitro preparation of peripheral airways: a comparison of beta-adrenoceptor agonists, autacoids and anaphylactic challenge on the lung strip and trachea.

Authors:  K M Lulich; H W Mitchell; M P Sparrow
Journal:  Br J Pharmacol       Date:  1976-09       Impact factor: 8.739

7.  Role of platelets in aspirin-sensitive bronchoconstriction in the guinea-pig; interactions with salicylic acid.

Authors:  J Lefort; B B Vargaftig
Journal:  Br J Pharmacol       Date:  1978-05       Impact factor: 8.739

8.  BRONCHOCONSTRICTOR ACTION AND ANTAGONISM OF A SLOW-REACTING SUBSTANCE FROM ANAPHYLAXIS OF GUINEA-PIG ISOLATED LUNG.

Authors:  P A BERRY; H O COLLIER
Journal:  Br J Pharmacol Chemother       Date:  1964-08

9.  The interaction of IgE antibody with human alveolar macrophages and its participation in the inflammatory processes of lung allergy.

Authors:  M Joseph; A B Tonnel; A Capron; J P Dessaint
Journal:  Agents Actions       Date:  1981-12

10.  Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro.

Authors:  J M Drazen; K F Austen; R A Lewis; D A Clark; G Goto; A Marfat; E J Corey
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

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