Literature DB >> 6896114

Leukotrienes C and D induce bronchoconstriction in man.

M C Holroyde, R E Altounyan, M Cole, M Dixon, E V Elliott.   

Abstract

Pulmonary responses to aerosols of synthetic leukotrienes C and D were examined in two normal volunteers. The leukotrienes were equipotent and equieffective in producing moderate bronchoconstriction accompanied by coughing. Changes in FEV1 were slight, but changes in expiratory flow at low lung volumes were more notable. FPL 55712 abolished the cough response and partially inhibited the bronchoconstriction.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 6896114     DOI： 10.1007/bf01978746

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  7 in total

1.  Slow reacting substance and related compounds.

Authors:  W E BROCKLEHURST
Journal:  Prog Allergy       Date:  1962

Review 2.  Assessment of changes in airway calibre I. Tests of forced expiration.

Authors:  N B Pride
Journal:  Br J Clin Pharmacol       Date:  1979-09       Impact factor: 4.335

3.  Selective inhibitor of slow reacting substance of anaphylaxis.

Authors:  J Augstein; J B Farmer; T B Lee; P Sheard; M L Tattersall
Journal:  Nat New Biol       Date:  1973-10-17

4.  Antigen induced release of histamine and SRS-A from human lung passively sensitized with reaginic serum.

Authors:  P Sheard; P G Killingback; A M Blair
Journal:  Nature       Date:  1967-10-21       Impact factor: 49.962

5.  Slow-reacting substances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitro.

Authors:  C J Hanna; M K Bach; P D Pare; R R Schellenberg
Journal:  Nature       Date:  1981-03-26       Impact factor: 49.962

6.  Slow reacting substances of anaphylaxis: identification of leukotrienes C-1 and D from human and rat sources.

Authors:  R A Lewis; K F Austen; J M Drazen; D A Clark; A Marfat; E J Corey
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

7.  Leukotrienes are potent constrictors of human bronchi.

Authors:  S E Dahlén; P Hedqvist; S Hammarström; B Samuelsson
Journal:  Nature       Date:  1980-12-04       Impact factor: 49.962
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.