Literature DB >> 6896071

Pharmacokinetics of sulfaethidole in the rat: nonlinear multicompartment solution.

M Kekki, R J Julkunen, H Pohjanpalo.   

Abstract

Sulfaethidole distribution and elimination in the rat was studied over a 90-fold dose range. This experimental design produced marked nonlinearity in the binding of sulfaethidole to proteins in both interstitial fluid an plasma. Using a multicompartmental model consisting of binding of sulfaethidole to plasma and interstitial fluid proteins, sulfaethidole distribution in the body could be simulated. Urinary and biliary elimination of sulfaethidole depended on the unbound drug mass in the plasma and urine flow. The results confirm the central role of the unbound species in the distribution and elimination of drugs with marked binding to plasma proteins.

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Year:  1982        PMID： 6896071     DOI： 10.1007/bf01059182

Source DB:  PubMed          Journal:  J Pharmacokinet Biopharm        ISSN： 0090-466X


  16 in total

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Authors:  E KRUEGER-THIEMER; W DILLER; L DETTLI; P BUENGER; J SEYDEL
Journal:  Antibiot Chemother       Date:  1964

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Authors:  J V SWINTOSKY; M J ROBINSON; E L FOLTZ; S M FREE
Journal:  J Am Pharm Assoc Am Pharm Assoc       Date:  1957-07

Review 3.  Kinetic analysis of turnover data.

Authors:  M Berman
Journal:  Prog Biochem Pharmacol       Date:  1979

4.  Distribution pharmacokinetics of warfarin in the rat, a non-linear multicompartment model.

Authors:  M Kekki; R J Julkunen; B Wahlström
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-03       Impact factor: 3.000

5.  Transport and binding of methotrexate in vivo.

Authors:  R L Dedrick; D S Zaharko; R J Lutz
Journal:  J Pharm Sci       Date:  1973-06       Impact factor: 3.534

6.  Explanation of dose-dependent decline of diphenylhydantoin plasma levels by fitting to the integrated form of the Michaelis-Menten equation.

Authors:  N Gerber; J G Wagner
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1972-05

7.  Methotrexate pharmacokinetics.

Authors:  K B Bischoff; R L Dedrick; D S Zaharko; J A Longstreth
Journal:  J Pharm Sci       Date:  1971-08       Impact factor: 3.534

8.  Pharmacokinetic models regarding protein binding of drugs.

Authors:  E Krüger-Thiemer; W Diller; P Bünger
Journal:  Antimicrob Agents Chemother (Bethesda)       Date:  1965

9.  [Solution of pharmacological problems by computers. 6. Models for the effect of protein binding on the clearance of drugs].

Authors:  E Krüger-Thiemer
Journal:  Arzneimittelforschung       Date:  1966-11

10.  The kinetics of methotrexate distribution in spontaneous canine lymphosarcoma.

Authors:  R J Lutz; R L Dedrick; J A Straw; M M Hart; P Klubes; D S Zaharko
Journal:  J Pharmacokinet Biopharm       Date:  1975-04
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  3 in total

1.  Generalized pharmacokinetic modeling for drugs with nonlinear binding: I. Theoretical framework.

Authors:  W R Gillespie
Journal:  J Pharmacokinet Biopharm       Date:  1993-02

2.  The deterministic identifiability of nonlinear pharmacokinetic models.

Authors:  K R Godfrey; W R Fitch
Journal:  J Pharmacokinet Biopharm       Date:  1984-04

3.  Pharmacokinetics of amikacin in serum and in tissue contiguous with pressure sores in humans with spinal cord injury.

Authors:  J L Segal; S R Brunnemann; I M Eltorai
Journal:  Antimicrob Agents Chemother       Date:  1990-07       Impact factor: 5.191
  3 in total

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