| Literature DB >> 6895900 |
A F Fuller, S Guy, G P Budzik, P K Donahoe.
Abstract
Mullerian inhibiting substance (MIS), a fetal testicular product which causes regression of the Mullerian duct in the male mammalian embryo, is being evaluated as an inhibitor of genital tract tumors. The present study demonstrates in a clonogenic soft agar that biologically active MIS inhibits the growth of a human ovarian carcinoma cell line (HOC-21) in a dose-dependent manner when compared to phosphate-buffered saline medium controls, heat-inactivated MIS, or biochemical fractions which lack biological activity (P less than 0.05).Entities:
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Year: 1982 PMID： 6895900 DOI： 10.1210/jcem-54-5-1051
Source DB: PubMed Journal: J Clin Endocrinol Metab ISSN： 0021-972X Impact factor: 5.958