Literature DB >> 6895624

8-phenyltheophylline: a potent P1-purinoceptor antagonist.

S G Griffith, P Meghji, C J Moody, G Burnstock.   

Abstract

8-Phenyltheophylline was more potent than theophylline in antagonizing the inhibitory effects of adenosine in guinea-pig driven left atrium, rabbit basilar artery and electrically stimulated guinea-pig ileum preparations. In guinea-pig atrium and ileum, the antagonism of adenosine responses by the methylxanthines is of a competitive nature, but in rabbit basilar artery it does not appear to be so. In all three preparations, the effects of theophylline and 8-phenyltheophylline could be reversed by washing. It is concluded that 8-phenyltheophylline is a more potent P1-purinoceptor antagonist than theophylline.

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Year:  1981        PMID： 6895624     DOI： 10.1016/0014-2999(81)90346-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  42 in total

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8.  Evidence that the P1-purinoceptor in the guinea-pig taenia coli is an A2-subtype.

Authors:  G Burnstock; J M Hills; C H Hoyle
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9.  Dual effect of (-)-N6-phenylisopropyl adenosine on guinea-pig trachea.

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