Literature DB >> 6895486

A phase II trial of m-AMSA in head and neck cancer.

A A Forastiere, C W Young, R E Wittes.   

Abstract

Twenty patients with advanced epidermoid carcinoma from primary sites in the head and neck region received adequate trials of therapy with m-AMSA, at starting doses of 90 or 120 mg/m2. Despite the good median performance status of the group (median 80) and the fact that 50% of the patients had received no prior chemotherapy, only one minor response was achieved. AMSA appears to have no useful activity in this dose and schedule in patients with epidermoid head and neck cancer.

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Year:  1981        PMID: 6895486     DOI: 10.1007/bf00262333

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN: 0344-5704            Impact factor:   3.333


  6 in total

1.  Phase 1 clinical investigation of 4'-(9-acridinylamino)methanesulfon-m-anisidide (NSC 249992), a new acridine derivative.

Authors:  S S Legha; J U Gutterman; S W Hall; R S Benjamin; M A Burgess; M Valdivieso; G P Bodey
Journal:  Cancer Res       Date:  1978-11       Impact factor: 12.701

2.  The experimental antitumour properties of three congeners of the acridylmethanesulphonanilide (AMSA) series.

Authors:  B F Cain; G J Atwell
Journal:  Eur J Cancer       Date:  1974-08       Impact factor: 9.162

3.  Phase I study of methanesulfonamide, N-[4-(9-acridinylamino)-3-methoxyphenyl]-(m-AMSA) using a single-dose schedule.

Authors:  D D Von Hoff; K Howser; P Gormley; R A Bender; D Glaubiger; A S Levine; R C Young
Journal:  Cancer Treat Rep       Date:  1978-10

4.  Phase II study of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) in metastatic breast cancer.

Authors:  S S Legha; G R Blumenschein; A U Buzdar; G N Hortobagyi; G P Bodey
Journal:  Cancer Treat Rep       Date:  1979 Nov-Dec

5.  Phase I evaluation of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) by a weekly iv dose schedule.

Authors:  T M Woodcock; R J Schneider; C W Young
Journal:  Cancer Treat Rep       Date:  1980-01

6.  Phase II. Evaluation of 4'-(9-acridinylamino)-methanesulfon-m-anisidide (AMSA) in patients with advanced sarcoma.

Authors:  P P Sordillo; G B Magill; R J Gralla; R B Golbey
Journal:  Cancer Treat Rep       Date:  1980 Oct-Nov
  6 in total
  2 in total

1.  Effectiveness of AMSA alone or in combination with radiation on murine fibrosarcoma pulmonary nodules.

Authors:  D J Grdina; S Jones; N Hunter
Journal:  Clin Exp Metastasis       Date:  1984 Jul-Sep       Impact factor: 5.150

2.  Phase II trial of N-methylformamide in advanced head and neck cancer.

Authors:  W C Vogel; A A Forastiere; R B Natale; B J Takasugi; G Schnur
Journal:  Invest New Drugs       Date:  1987       Impact factor: 3.850

  2 in total

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