Literature DB >> 6895224

Metabolism of leukotriene D by porcine kidney.

K Bernström, S Hammarström.   

Abstract

An enzyme from porcine kidney converted leukotriene D4 into a less polar metabolite. The structure of this compound was 5-hydroxy-6-S-cysteinyl-7,9-trans-11,14-cis-eicosatetraenoic acid (leukotriene E4). Analogous products, viz. 5-hydroxy-6-S-cysteinyl-7,9,11-eicosatrienoic acid (leukotriene E3), 5-hydroxy-6-S-cysteinyl-7,9,11-trans-14-cis-eicosatetraenoic acid (11-trans-leukotriene E4), and 5-hydroxy-6-S-cysteinyl-7,9,11,14,17-eicosapentaenoic acid (leukotriene E5) were formed from leukotrienes D3, 11-trans-D4, and D5, respectively. Leukotriene E4 induced slow reacting substance-like contractions of guinea pig ileum but was less potent (8-12 times) than leukotriene C4. The biological potency of 11-trans-leukotriene E4 was similar to that of leukotriene E4.

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Year:  1981        PMID： 6895224

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  12 in total

1.  Leukotrienes in teleost fish gills.

Authors:  D Piomelli
Journal:  Naturwissenschaften       Date:  1985-05

2.  Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma.

Authors:  A S Cowburn; K Sladek; J Soja; L Adamek; E Nizankowska; A Szczeklik; B K Lam; J F Penrose; F K Austen; S T Holgate; A P Sampson
Journal:  J Clin Invest       Date:  1998-02-15       Impact factor: 14.808

3.  Renal vascular effects of leukotriene C4 in the isolated perfused kidney of the rat.

Authors:  J C Frölich; M Yoshizawa
Journal:  Br J Pharmacol       Date:  1987-10       Impact factor: 8.739

4.  Subcellular localization of enzymes involved in leukotriene formation within human polymorphonuclear granulocytes.

Authors:  J Brom; M Raulf; M Stüning; B Spur; A Crea; K D Bremm; W König
Journal:  Immunology       Date:  1984-03       Impact factor: 7.397

5.  Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids.

Authors:  M E Anderson; R D Allison; A Meister
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

Review 6.  The biologically active leukotrienes. Biosynthesis, metabolism, receptors, functions, and pharmacology.

Authors:  R A Lewis; K F Austen
Journal:  J Clin Invest       Date:  1984-04       Impact factor: 14.808

7.  Bioconversion of C-6 sulfidopeptide leukotrienes by the responding guinea pig ileum determines the time course of its contraction.

Authors:  S Krilis; R A Lewis; E J Corey; K F Austen
Journal:  J Clin Invest       Date:  1983-04       Impact factor: 14.808

8.  Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine.

Authors:  Sonia R Salvatore; Dario A Vitturi; Paul R S Baker; Gustavo Bonacci; Jeffrey R Koenitzer; Steven R Woodcock; Bruce A Freeman; Francisco J Schopfer
Journal:  J Lipid Res       Date:  2013-04-25       Impact factor: 5.922

9.  Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes.

Authors:  C W Lee; R A Lewis; E J Corey; K F Austen
Journal:  Immunology       Date:  1983-01       Impact factor: 7.397

10.  Leukotrienes in the rat central nervous system.

Authors:  J A Lindgren; T Hökfelt; S E Dahlén; C Patrono; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1984-10       Impact factor: 11.205
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