Literature DB >> 6894570

Production of a polar metabolite of 1,25-dihydroxyvitamin D3 in a rat liver perfusion system.

R Kumar, S Nagubandi, J M Londowski.   

Abstract

When radiolabeled 1,25-dihydroxyvitamin D3 is added to the perfusion medium of a rat liver perfusion system, a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver and excreted in the bile. Addition of radiolabeled 1,25-dihydroxyvitamin D3 to the perfusion medium without a liver in the circuit results in no formation of the polar metabolite. These data suggest that a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver prior to being excreted in bile. Moreover, it is likely that polar metabolites of 1,25-dihydroxyvitamin D3 present in the bile of rats in vivo are formed in the liver.

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Year:  1981        PMID： 6894570     DOI： 10.1007/bf01391637

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  8 in total

1.  Isolated rat liver preparation; bile production and other basic properties.

Authors:  R W BRAUER; R L PESSOTTI; P PIZZOLATO
Journal:  Proc Soc Exp Biol Med       Date:  1951-10

Review 2.  Metabolism and mechanism of action of vitamin D.

Authors:  H F DeLuca; H K Schnoes
Journal:  Annu Rev Biochem       Date:  1976       Impact factor: 23.643

3.  Biological activity of 1,25-dihydroxycholecalciferol.

Authors:  J Omdahl; M Holick; T Suda; Y Tanaka; H F DeLuca
Journal:  Biochemistry       Date:  1971-07-20       Impact factor: 3.162

4.  25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties.

Authors:  R W Gray; J L Omdahl; J G Ghazarian; H F DeLuca
Journal:  J Biol Chem       Date:  1972-12-10       Impact factor: 5.157

5.  25-Hydroxyvitamin D3: evidence of an enterohepatic circulation in man.

Authors:  S B Arnaud; R S Goldsmith; P W Lambert; V L Go
Journal:  Proc Soc Exp Biol Med       Date:  1975-06

6.  Enterohepatic physiology of 1,25-dihydroxyvitamin D3.

Authors:  R Kumar; S Nagubandi; V R Mattox; J M Londowski
Journal:  J Clin Invest       Date:  1980-02       Impact factor: 14.808

7.  Metabolism of vitamin D3-3H in human subjects: distribution in blood, bile, feces, and urine.

Authors:  L V Avioli; S W Lee; J E McDonald; J Lund; H F DeLuca
Journal:  J Clin Invest       Date:  1967-06       Impact factor: 14.808

8.  Investigations on metabolites of vitamin D in rat bile. Separation and partial identification of a major metabolite.

Authors:  P A Bell; E Kodicek
Journal:  Biochem J       Date:  1969-12       Impact factor: 3.857
  8 in total
  3 in total

Review 1.  Vitamin D and the kidney.

Authors:  Rajiv Kumar; Peter J Tebben; James R Thompson
Journal:  Arch Biochem Biophys       Date:  2012-03-15       Impact factor: 4.013

Review 2.  Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment.

Authors:  Peter J Tebben; Ravinder J Singh; Rajiv Kumar
Journal:  Endocr Rev       Date:  2016-09-02       Impact factor: 19.871

3.  1,25 dihydroxyvitamin D-induced inhibition of 3H-25 hydroxyvitamin D production by the rachitic rat liver in vitro.

Authors:  D T Baran; M L Milne
Journal:  Calcif Tissue Int       Date:  1983-07       Impact factor: 4.333
  3 in total

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