Literature DB >> 6893963

Intrathecal morphine in mice: a new technique.

J L Hylden, G L Wilcox.   

Abstract

A simple, rapid technique for intrathecal injections by lumbar puncture in unanesthetized mice is described. Intrathecal [3H]morphine base was not found in significant quantities in either the midbrain or forebrain. Submicrogram quantities of morphine sulfate induced Straub tail response and tail-flick analgesia. These effects were dose related and antagonized by subcutaneous naloxone.

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Year:  1980        PMID： 6893963     DOI： 10.1016/0014-2999(80)90515-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  431 in total

1.  In vivo pathway of thermal hyperalgesia by intrathecal administration of alpha,beta-methylene ATP in mouse spinal cord: involvement of the glutamate-NMDA receptor system.

Authors:  M Tsuda; S Ueno; K Inoue
Journal:  Br J Pharmacol       Date:  1999-05       Impact factor: 8.739

2.  Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception.

Authors:  Arpad Dobolyi; Hiroshi Ueda; Hitoshi Uchida; Miklós Palkovits; Ted B Usdin
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-29       Impact factor: 11.205

3.  Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice.

Authors:  F Karim; C C Wang; R W Gereau
Journal:  J Neurosci       Date:  2001-06-01       Impact factor: 6.167

4.  Involvement of spinal protein kinase Cgamma in the attenuation of opioid mu-receptor-mediated G-protein activation after chronic intrathecal administration of [D-Ala2,N-MePhe4,Gly-Ol(5)]enkephalin.

Authors:  M Narita; H Mizoguchi; M Narita; H Nagase; T Suzuki; L F Tseng
Journal:  J Neurosci       Date:  2001-06-01       Impact factor: 6.167

5.  The activation of supraspinal GPR40/FFA1 receptor signalling regulates the descending pain control system.

Authors:  K Nakamoto; T Nishinaka; N Sato; F Aizawa; T Yamashita; M Mankura; Y Koyama; F Kasuya; S Tokuyama
Journal:  Br J Pharmacol       Date:  2015-01-12       Impact factor: 8.739

6.  The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy.

Authors:  L S Stone; L B MacMillan; K F Kitto; L E Limbird; G L Wilcox
Journal:  J Neurosci       Date:  1997-09-15       Impact factor: 6.167

7.  Evidence for the modulation of nociception in mice by central mast cells.

Authors:  C L Kissel; K J Kovács; A A Larson
Journal:  Eur J Pain       Date:  2017-07-19       Impact factor: 3.931

8.  Spinal alpha(2)-adrenergic and muscarinic receptors and the NO release cascade mediate supraspinally produced effectiveness of gabapentin at decreasing mechanical hypersensitivity in mice after partial nerve injury.

Authors:  Keiko Takasu; Motoko Honda; Hideki Ono; Mitsuo Tanabe
Journal:  Br J Pharmacol       Date:  2006-05       Impact factor: 8.739

9.  Toll-like receptor 2 mediates peripheral nerve injury-induced NADPH oxidase 2 expression in spinal cord microglia.

Authors:  Hyoungsub Lim; Donghoon Kim; Sung Joong Lee
Journal:  J Biol Chem       Date:  2013-02-05       Impact factor: 5.157

10.  Antagonists of the kappa-opioid receptor enhance allodynia in rats and mice after sciatic nerve ligation.

Authors:  I Obara; J Mika; M K-H Schafer; B Przewlocka
Journal:  Br J Pharmacol       Date:  2003-09-01       Impact factor: 8.739
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