Literature DB >> 6893559

Intrathecal morphine as sole analgesic during labour.

P V Scott, F E Bowen, P Cartwright, B C Rao, D Deeley, H G Wotherspoon, I M Sumrein.   

Abstract

In 12 consecutive unselected patients admitted to a consultant maternity unit one single injection of subarachnoid morphine sulphate 1.5 mg abolished pain during the first stage of labour. Pain in the second stage was abolished in four patients and lessened in three. During the early puerperium, pain at the site of the episitotomy was much reduced. Side effects included itching of the face, nausea and vomiting, and frontal headache, but these were mild and simply treated. They were even less severe in the last four patients, in whom barbotage was not used in administering the morphine. The high rate of forceps delivery and caesarean section (three cases of each) was not thought to be associated with the use of intrathecal morphine. These findings show that intrathecal morphine can abolish the pain of labour, whether spontaneous or induced, while preserving the mother's full awareness of labour and her co-operation in the second and third stages of labour. Further, controlled, trials are warranted.

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Year:  1980        PMID: 6893559      PMCID: PMC1713526          DOI: 10.1136/bmj.281.6236.351

Source DB:  PubMed          Journal:  Br Med J        ISSN: 0007-1447


  3 in total

1.  Opiate receptors and internal opiates.

Authors:  S H Snyder
Journal:  Sci Am       Date:  1977-03       Impact factor: 2.142

2.  Selective spinal analgesia.

Authors:  K Samii; J Feret; A Harari; P Viars
Journal:  Lancet       Date:  1979-05-26       Impact factor: 79.321

3.  Failure of epidural morphine to relieve pain in labour.

Authors:  R P Husemeyer; M C O'Connor; H T Davenport
Journal:  Anaesthesia       Date:  1980-02       Impact factor: 6.955

  3 in total
  14 in total

Review 1.  Intrathecal opioids for combined spinal-epidural analgesia during labour.

Authors:  Peter DeBalli; Terrance W Breen
Journal:  CNS Drugs       Date:  2003       Impact factor: 5.749

2.  Clinical experience of epidural fentanyl for labor pain.

Authors:  K Murakawa; T K Abboud; T Yanagi; F Sarkis; A Afrasiabi; A Sheikh-ol-Eslam; J Raya; M L Yonekura
Journal:  J Anesth       Date:  1987-03-01       Impact factor: 2.078

3.  The TFOS International Workshop on Contact Lens Discomfort: report of the subcommittee on neurobiology.

Authors:  Fiona Stapleton; Carl Marfurt; Blanka Golebiowski; Mark Rosenblatt; David Bereiter; Carolyn Begley; Darlene Dartt; Juana Gallar; Carlos Belmonte; Pedram Hamrah; Mark Willcox
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-10-18       Impact factor: 4.799

4.  Analgesic effect of epidural morphine in lumbar disc surgery.

Authors:  A Sepehrnia; W J van Ouwerkerk
Journal:  Neurosurg Rev       Date:  1996       Impact factor: 3.042

5.  Intrathecal morphine in labour--efficacy and side effects.

Authors:  E G Carton; N McDonald; J R McCarthy
Journal:  Ir J Med Sci       Date:  1987-11       Impact factor: 1.568

Review 6.  Recent developments in analgesia during labour.

Authors:  R E Kan; S C Hughes
Journal:  Drugs       Date:  1995-09       Impact factor: 9.546

7.  Intraspinal opiates and itching: a new reflex?

Authors:  D M Justins; F Reynolds
Journal:  Br Med J (Clin Res Ed)       Date:  1982-05-08

Review 8.  Spinal opiate analgesia and facial pruritus: a neural theory.

Authors:  P V Scott; H B Fischer
Journal:  Postgrad Med J       Date:  1982-09       Impact factor: 2.401

Review 9.  Newer methods of delivery of opiates for relief of pain.

Authors:  P J Slattery; R A Boas
Journal:  Drugs       Date:  1985-12       Impact factor: 9.546

10.  Itch elicited by intradermal injection of serotonin, intracisternal injection of morphine, and their synergistic interactions in rats.

Authors:  H R Moser; G J Giesler
Journal:  Neuroscience       Date:  2014-05-27       Impact factor: 3.590

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